摘要：背景：幼年系统性红斑狼疮（JSLE）的慢性炎症病程及长期糖皮质激素治疗可导致患儿生长抑制。本研究的目的是评价17岁JSLE患者（诊断时11岁）生长激素（GH）治疗一年对其生长率的改善情况。

病例介绍：患者11岁时出现生长放缓（十岁时生长是正常的，在50百分位）。此后，身高的增长速度平均为1cm/年。在16岁时（GH治疗前）身高为148cm（第3百分位以下）。依据骨龄图谱，其骨龄大约相当于11年。患者在内分泌门诊接受激素检测，包括刺激垂体生长激素储备测试，结果提示其应接受每周30IU的生长激素治疗。在治疗的6个月内，其身高增加7.5cm且最终身高达到161cm。在治疗期间无JSLE加重或糖耐量紊乱，唯一的副作用为在治疗第一周时的强烈口渴和短暂下肢水肿。同时，患者的总体感觉有所改善。

结论：患者经过一年的生长激素治疗后，身高达到正常水平，同时伴随者体重减轻且没有明显副作用。

附全文：INTRODUCTION: A chronic autoimmune inflammatory process and a long-term steroid therapy seems to underlie growth inhibition in children suffering from juvenile systemic lupus erythematosus (JSLE). The study objective was to assess the effect of one-year GH therapy on the growth rate in a 17-year-old girl with JSLE diagnosed when she was 11. CASE DESCRIPTION: Growth rate slowdown was observed when the girl was eleven (up to the age of 10 the growth was harmonious--50 centile). Since then, the mean gain in body height was approximately 1 cm/year. At the age of 16 (prior to the start of GH therapy), she was 148 cm high (below 3 centile), telarche II degrees, pubarche I degrees. The skeletal age corresponded to approximately 11 years according to the method of Greulich-Pyle. The girl underwent hormonal examinations in the Endocrinology Outpatient Department, including stimulatory tests of pituitary GH reserve, and based on the findings she was qualified for GH therapy, at a weekly dose of 30 IU. Within the 6-month-therapy, the patient grew by 7.5 cm, with the final outcome of 161 cm. The period of treatment was free of JSLE exacerbations or glucose tolerance disturbances. The only side effects included enhanced thirst and transitory oedema of the lower extremities observed in the first week of therapy. At the same time the patient's general feeling improved. CONCLUSIONS: During a one-year GH therapy, the girl achieved catch-up growth, which was accompanied by body weight reduction and no significant side effects.

摘自：Górska A, Gardziejczyk M, Urban M. Growth hormone administration in the treatment of growth retardation in juvenile SLE--case history. Pediatr Endocrinol Diabetes Metab. 2007;13(3):171-3.