摘要：美国纽约医科大学的Sperber K等对风湿病女性患者妊娠期间使用羟氯喹与婴儿发生先天性缺陷、流产、胎儿活产、死胎和早产等相关性进行了全面检索和综述，检索时间为1980年到2007年，检索词为羟氯喹和（或）妊娠，检索数据库包括MEDLINE、Cochrance、Ovid、 EBSCO、SCOPUS和科学网等。所有数据均按照标准化的形式提取和验证。 结果显示，接受羟氯喹治疗的女性妊娠期间活产婴儿发生先天性缺陷的优势比（OR）为0.66（95%的可信区间为0.25-1.75），活产的OR为1.05（95%的可信区间为0.58-1.93），流产的OR为0.92（95%的可信区间0.49-1.72），死胎的OR为0.97（95%的可信区间为0.14-6.54），早产的OR 为1.10（95%的可信区间为0.75-1.61）。

该研究表明，风湿病女性患者妊娠期间，使用羟氯喹与婴儿发生先天性缺陷、流产、胎儿活产、死胎和早产等风险增加无关，也与活产率降低无关。

附摘要： ABSTRACT: OBJECTIVE: The purpose of this study is to compare the incidence of congenital defects, spontaneous abortions, number of live births, fetal death and pre-maturity in women with autoimmune diseases taking HCQ during pregnancy. METHODS: The authors searched MEDLINE, Cochrane data base, Ovid-Currents Clinical Medicine, Ovid-Embase:Drugs and Pharmacology, EBSCO, Web of Science, and SCOPUS using the search terms HCQ and/or pregnancy. We attempted to identify all clinical trials from 1980 to 2007 regardless of language or publication status. We also searched Cochrane Central Library and http://www.Clinical trials.gov for clinical trials of HCQ and pregnancy. Data were extracted onto standardized forms and were confirmed. RESULTS: The odds ratio (OR) of congenital defects in live births of women taking HCQ during pregnancy was 0.66, 95% confidence intervals (CI) 0.25, 1.75. The OR of a live birth for women taking HCQ during pregnancy was 1.05 (95% CI 0.58, 1.93). The OR of spontaneous abortion in women taking HCQ during pregnancy was 0.92 (95% CI 0.49, 1.72). The OR of fetal deaths in women taking HCQ during pregnancy was 0.97 (95% CI 0.14, 6.54). The OR of pre-mature birth defined as birth before 37 weeks in women taking HCQ during pregnancy was 1.10 (95% CI 0.75, 1.61). CONCLUSION: HCQ is not associated with any increased risk of congenital defects, spontaneous abortions, fetal death, pre-maturity and decreased numbers of live births in patients with auto-immune diseases.

摘自：Sperber K, Hom C, Chao CP, et al.Systematic review of hydroxychloroquine use in pregnant patients with autoimmune diseases. Pediatr Rheumatol Online J. 2009 May 13;7:9.