头痛及脑血管病是狼疮脑病最常见的症状

作者：Fatemeh Hajighaemi, 翻译：北医三院李欣艺

摘要 背景：狼疮脑病是系统性红斑狼疮的严重的以及常见的并发症。以下是伊朗的关于狼疮脑病流行病学以及表现的数据。此研究目的旨在探讨伊朗人狼疮脑病的临床及流行病学特点。

资料及方法：此研究为横断面研究，自2004-03至2010-6期间，有狼疮记录的患者纳入研究。狼疮脑病以美国风湿病学会诊断标准诊断。采用描述性统计以及逻辑回归评价进行统计学评估。

结果：556名狼疮患者中有121名诊断狼疮脑病，其中94名为女性，27名为男性，男女比为3.48：1。狼疮脑病最常见的表现为头疼（38.8%），脑血管疾病（38.8%）以及癫痫发作（26.4%）。39名患者存在精神障碍，其中的32名有阶段性的精神疾患，6名患者具有心境障碍。

结论：狼疮脑病在狼疮患者中的发病率为21.7%。头痛及脑血管病是最常见的神经精神表现。关于狼疮脑病发病机制的研究需要进一步进行。

附原文：Background: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious and well-known complication of systemic lupus erythematosus (SLE). There is limited evidence about the prevalence of NPSLE and its manifestations in Iran. The aim of this study was to study clinical and demographic characteristics of patients with NPSLE in an Iranian population. Materials and Methods: This was a cross-sectional study that was undertaken in two referral Clinics of Neurological and Rheumatological Disorders in Alzahra Hospital, Isfahan, Iran. Between March 2004 and June 2010, medical records of registered patients with SLE were examined. NPSLE was characterized using the American College of Rheumatology case definitions. Descriptive statistics and logistic regression were performed for statistical assessment. Results: Among 556 patients with SLE, 121 (21.7%) patients were diagnosed as NPSLE and enrolled in the study. Of whom, 94 patients were female (77.7%) and 27 patients were male (22.3%) with a female to male ratio of 3.48:1. The most common NPSLE manifestations were headache (38.8%), cerebrovascular disease (CVD) (38.8%) and seizure (26.4%). Thirty-nine patients have psychiatric disorders. Among them, 32 patients (26.4%) have periods of psychosis and mood disorder was found in 6 patients (5%)..Conclusions: We identified NPSLE manifestations in 21.7% of patients; headache and CVD were the most frequent neurological manifestations. Continued studies into the pathogenesis of neurological involvement in patients with SLE are warranted.

引自：Fatemeh Hajighaemi, Masoud Etemadifar,1 and Zahra Sayed Bonakdar Neuropsychiatric manifestations in patients with systemic lupus erythematosus: A study from Iran Adv Biomed Res. 2016; 5: 43