摘要(来自德国的综述)：目的 探讨炎性风湿病（含类风湿关节炎、强直性脊柱炎和系统性红斑狼疮）怎样影响怀孕过程和胎儿发育。同时必须要考虑到孕妇所用的抗风湿药及胎儿合并症的防治策略。

最近发现 目前，不少文献资料探讨了类风湿关节炎和强直性脊柱炎患者怀孕期间风湿症状缓解或恶化的免疫机制。而系统性红斑方面，有几项关于抗磷脂综合症及抗SSA和抗SSB阳性母亲所生胎儿的合并症及其诊断、处理或预防。

总结 当前，患炎性风湿病的妇女具备正常生育力，当疾病稳定和静止情况下，应鼓励怀孕。近几十年来，狼疮患者怀孕结局有改观，这对题目来说尤为重要，不过，狼疮病程中怀孕的风险还是高的，尤其是有活动性狼疮肾炎的妇女怀孕风险更高。相反，多数情况下，女性类风湿关节炎患者的病情在怀孕期间是缓解的，女性强直性脊柱炎患者的背痛和功能损害则可能不变或恶化。

附原文：Abstract PURPOSE OF REVIEW: This review discusses how inflammatory rheumatic diseases [rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus (SLE)] of the mother can influence the course of pregnancy and the development of the fetus. Antirheumatic drug therapy of the mother and strategies to prevent fetal complications namely in SLE must be considered with care. RECENT FINDINGS: The current literature is presented discussing hypotheses about the immunologic mechanisms leading to amelioration or exacerbation of the rheumatic symptoms in rheumatoid arthritis and ankylosing spondylitis during pregnancy. In SLE, several recent studies have been published concerning fetal complications in the antiphospholipid syndrome and in Ro/SSA-positive and La/SSB-positive mothers and how to diagnose, treat, or prevent these. SUMMARY: Today, women with inflammatory rheumatic diseases are normally fertile and can be encouraged to become pregnant, when there is a stable and quiescent phase of the disease. This is in particular important for patients with SLE, although pregnancy outcome in SLE has improved over the last decades. Pregnancy in SLE is still a high-risk period during the disease course with the highest risk in women with active lupus nephritis. In contrast, women with rheumatoid arthritis develop amelioration of the rheumatic symptoms during the course of pregnancy in most cases; female ankylosing spondylitis patients are likely to show unaltered or aggravated symptoms of back pain and impaired function.

摘自：M?rker-Hermann E, Fischer-Betz R. Rheumatic diseases and pregnancy. Curr Opin Obstet Gynecol， 2010 Oct 16. [Epub ahead of print]