工作经历：2013年7月获大连医科大学临床医学专业学士学位，2018年获北京大学医学部人体解剖与组织胚胎学系博士学位，2020年6月于北京大学医学部完成博士后研究。2020年7月入职北医三院中心实验室工作至今。现任副研究员/助理教授，负责肿瘤类器官平台的构建工作。

科研工作：围绕“肿瘤发生、转移和耐药的分子机制及转化医学方向”开展基础研究。主持国自然面上基金，国自然青年基金，博士后面上基金，北京大学天然药物及仿生药物国家重点实验室开放基金等基金项目，参与国自然重点、国自然面上、北自然面上基金等7项基金项目。以第一或通讯作者发表论文7篇。

学术兼职：担任中国抗癌协会肿瘤转移专业委员会青年委员、中国生理学会基质生物学专业委员会青年学组成员，《Frontiers in Pharmacology》客座编委。

代表性论文：

1. 第一/通讯作者论文

（1）Jiagui Song, Tianzhuo Wang, Xiaochun Chi, Xiaofan Wei, Sidi Xu, Miao Yu, Huiying He, Ji Ma, Xueying Li, Juan Du, Xiaoran Sun, Yunling Wang, Jun Zhan*, Hongquan Zhang*. Kindlin-2 inhibits the Hippo signaling pathway via promoting degradation of MOB1. Cell Rep. 2019 Dec 10;29(11):3664-3677. IF: 8.8, Q1

（2）Jiagui Song, Tianzhuo Wang, Weizhi Xu, Peng Wang, Junhu Wan, Yunling Wang, Jun Zhan*, Hongquan Zhang*. HOXB9 acetylation at K27 is responsible for its suppression of colon cancer progression. Cancer Lett. 2018 Jul 10;426:63-72. IF: 9.7, Q1

（3）Wenhao Xia^#, Hao Wang^#, Xiaozhu Zhou, Yan Wang, Lixiang Xue*, Baoshan Cao*, Jiagui Song*. The role of cholesterol metabolism in tumor therapy, from bench to bed. Front Pharmacol. 2023 Apr 6;14:928821. IF: 5.6, Q1

（4）Chen Li^#, Jiagui Song^#, Zhengyang Guo, Yueqing Gong, Tengrui Zhang, Jiaqi Huang, Rui Cheng, Xiaotong Yu, Yanfang Li, Li Chen, Xiaojuan Ma, Yan Sun,Yan Wang, Lixiang Xue. EZH2 inhibitors suppress colorectal cancer by regulating macrophage polarization in tumor microenvironment. Frontiers Immunology. 2022 Apr 1:13:857808. IF: 7.3, Q1

（5）Jing Zhang^#，Jiagui Song ^#，Zhenbin Wang, Yuqing Gong, Tianzhuo Wang, JY Zhou, Jun Zhan*, and Hongquan Zhang*. Kindlin-2 regulates endometrium development via mTOR and Hippo signaling pathways in mice. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. Volume 54, Issue 5. 2022. PP 846-852. 中文核心

（6）Xiaochun Chi^#, Weiwei Luo^#, Jiagui Song^#, Bing Li^#, Tiantian Su, Miao Yu, Tianzhuo Wang, Zhenbin Wang, Cheng Liu, Zhen Li, Hui-Ying He, Jun Zhan*, and Hongquan Zhang*. Kindlin-2 in Sertoli cells is essential for testis development and male fertility in mice. Cell Death Dis. 2021 Jun 11;12(6):604. IF: 9, Q1

（7）Zhenbin Wang ^#, Lei Zhang ^#, Bing Li ^#, Jiagui Song ^#, Miao Yu, Jing Zhang, Ceshi Chen*, Jun Zhan*, Hongquan Zhang*. Kindlin-2 in myoepithelium controls luminal progenitor commitment to alveoli in mouse mammary gland. Cell Death Dis.2023 Oct 13;14(10):675. IF: 9, Q1

2. 参与作者论文

(1) Xiaokun He, Jiagui Song, Zeyu Cai, Xiaochun Chi, Zhenbin Wang, Decao Yang, Sian Xie, Jing Zhou, Yi Fu, Wei Li, Wei Kong, Jun Zhan*, Hongquan Zhang*.Kindlin-2 deficiency induces fatal intestinal obstruction in mice. Theranostics. 2020;10(14): 6182-6200. IF: 12.4, Q1

(2) Xiaoran Sun, Jiagui Song, Jing Zhang, Jun Zhan*, Weigang Fang*, Hongquan Zhang*. Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal adenocarcinoma. Front Med. 2020 Feb;14(1):91-100. IF: 8.1, Q1

(3) Jun Zhan, Jiagui Song, Peng Wang, Xiaochun Chi, Yunling Wang, Yongqing Guo, Weigang Fang*, Hongquan Zhang*. Kindlin-2 induced by TGF-β signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9. Cancer Lett. 2015 May 28;361(1):75-85. IF: 9.7, Q1

(4) Bing Li, Xiaochun Chi, Jiagui Song, Yan Tang, Juan Du, Xiaokun He, Xiaoran Sun, Zhenwu Bi, Yunling Wang, Jun Zhan*, Hongquan Zhang*. Sci China Life Sci. 2019 Feb;62(2):225-234. IF:9.1, Q1

(5) Peng Wang, Jun Zhan, Jiagui Song, Yunling Wang, Weigang Fang*, Zhihua Liu*, Hongquan Zhang*. Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology. Sci China Life Sci. 2017 Nov;60(11):1214-1222. IF: 9.1, Q1

(6) Jun Zhan, Peng Wang, Shuai Li, Jiagui Song, Huiying He, Yunling Wang, Zhaofei Liu, Fan Wang, Hua Bai, Weigang Fang, Quan Du, Min Ye, Zhijie Chang, Jie Wang, Hongquan Zhang*. HOXB13 networking with ABCG1/EZH2/Slug mediates metastasis and confers resistance to cisplatin in lung adenocarcinoma patients. Theranostics. 2019 Apr 6;9(7):2084-2099. IF: 12.4, Q1

(7) Ji Ma, Cheng Liu, Decao Yang, Jiagui Song, Jing Zhang, Tianzhuo Wang, Mengyuan Wang, Weizhi Xu, Xueying Li, Shigang Ding*, Jun Zhan#, Hongquan Zhang#. C1orf106, an innate immunity activator, is amplified in breast cancer and is required for basal-like/luminal progenitor fate decision. Sci China Life Sci. 2019 Sep;62(9):1229-1242. IF: 9.1, Q1

(8) Hao Jiang, Tingting Li, Yi Qu, Xiang Wang, Bing Li, Jiagui Song, Xiaoran Sun, Yan Tang, Junhu Wan, Yu Yu, Jun Zhan, Hongquan Zhang*. Long non-coding RNA SNHG15 interacts with and stabilizes transcription factor Slug and promotes colon cancer progression. Cancer Lett. 2018 Jul 1;425:78-87. IF: 9.7, Q1

（9）Jiaqi Jin, Lei Zhang, Xueying Li, Weizhi Xu, Siyuan Yang, Jiagui Song, W Zhang, Jun Zhan*, Jianyuan Luo*, Hongquan Zhang*. Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway. Nucleic Acids Res. 2022 Apr 22;50(7):3817-3834. IF: 14.9, Q1

(10) Tianzhuo Wang, Huiying Guo, Q Li, Weijie Wu, Miao Yu, Lei Zhang, C Li, Jiagui Song, Zhenbin Wang, Jing Zhang, Yan Tang, L Kang, Hongquan Zhang*, Jun Zhan*. The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations. Cell Rep. 2022 Aug 23;40(8):111210. IF: 8.8, Q1

(11) Miao Yu, Weijie Wu, Y Sun, H Yan, Lei Zhang, Zhenbin Wang, Yueqing Gong, Tianzhuo Wang, Q Li, Jiagui Song, Mengyuan Wang, Jing Zhang, Yan Tang, Jun Zhan*, Hongquan Zhang*. FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth. Cell Rep. 2023 Aug 29;42(8):112886. IF: 8.8, Q1

(12) Baixi Shan, Zhifu Ai, Sufen Zeng, Yonggui Song^#, Jiagui Song, Qiang Zeng, Zhou Liao, Tingting Wang, Chao Huang, Dan Su^#. Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway. Psychoneuroendocrinology. 2020 Jul;117:104699. IF: 3.7, Q1

(13) Dan Su^#, Zhou Liao, Binwei Feng, Tingting Wang, Baixi Shan, Qiang Zeng, Jiagui Song, Yonggui Song. Pulsatilla chinensis saponins cause liver injury through interfering ceramide/sphingomyelin balance that promotes lipid metabolism dysregulation and apoptosis. Phytomedicine. 2020 Jun 15;76:153265. IF: 7.9, Q1

专利项目：

（1）宋佳桂; 瞿仪; 薛丽香 ; 一种96孔板上样辅助装置, 2021-10-11, 中国, 202120725335.5 ，实用新型专利，2023年完成转化，转化金额为20万元。

（2）薛丽香;霍霄;郭正阳;宋佳桂;宋颖;张腾瑞；包含EZH2抑制剂和多不饱和脂肪酸抑制剂的抗肿瘤药物组合物及其用途，2023-08-22，中国，ZL 2022 1 0682634.4，发明专利，已授权。

（3）宋佳桂; 李胤嘉; 薛丽香 ; 一种蛋白提取操作台, 2022-2-15, 中国, 202122586637.1 ，实用新型专利，已授权。

著作或译著：参编《新编医学常用实验技术》（在编）