工作经历:
2014年1月,获中国科学院微生物研究所生物化学与分子生物学专业博士学位;2015年11月-2016年10月,在美国MD Anderson Cancer Center学习;2019年4月,入职北京大学第三医院中心实验室工作至今,负责科室的临床技术委托方案评估及各平台技术服务的分工协作。
科研工作:围绕肿瘤免疫治疗抵抗开展肿瘤免疫治疗新策略研究。主持国家自然科学基金2项、北京市自然科学基金1项、河北省优秀青年基金、留学回国人员资助项目、北京大学医学交叉种子基金、北京大学第三医院创新转化基金等,参与科技部重点研发项目1项,以第一或通讯作者发表论文7篇。
学术兼职:
中华医学会微生物与免疫分会青年委员;
河北省肿瘤学会转化医学分会委员;
Oncogene、Molecular Cancer, Frontier in Immunology等杂志审稿;
获奖情况:
1.2023年,北京大学技术成果奖三等奖,第一完成人;
2.2017年,河北省三三三人才三层次;
3.2016年,中国免疫学会青年学者奖;
4.2009年,河北省科技进步二等奖,第七完成人;
代表性论文:
1.Jianling Yang, Jun Wang, Ke Chen, Guijie Guo, Ruijiao Xi, Paul B. Rothman, Douglas Whitten, Lianfeng Zhang, Shile Huang, and Ji-Long Chen*. eIF4B Phosphorylation by Pim Kinases Plays a Critical Role in Cellular Transformation by Abl Oncogenes. Cancer Research. 73(15):4898-4908, 2013.
2.Huang J, Zhang J, Guo Z, Li C, Tan Z, Wang J, Jianling Yang*, Lixiang Xue*. Easy or not-the advances of ezh2 in regulating t cell development, differentiation, and activation in antitumor immunity. Front Immunol, 2021;12:741302.
3.Zhengyang Guo, Jiaqi Huang, Xiao Huo, Xiaotong Yu, Tianhui He, Hongyan Guo,Jianling Yang*, Lixiang Xue*, Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin, Science China Life Science, 2023.
4.Jianling Yang#, Zhengyang Guo#, Xu Liu#, Meng Wu Qi Liu, Zhengyang Guo, Yang Liu, Xueting Yao, Haiyan Li, Chunli Song, Dongyang Liu, Lixiang Xue, Cytotoxicity evaluation of chloroquine and hydroxychloroquine in multiple cell lines and tissues by dynamic imaging system and PBPK model, Frontiers in Pharmacology, doi.org/10.3389/fphar. 2020. 574720.
5.Gong Yueqing#; Yang Jianling#; Wang Yan; Xue Lixiang*; Wang Junjie*; Metabolic Factors Contribute to T-cell Inhibition in the Ovarian Cancer Ascites,International Journal of Cancer. 2020 Mar 24. doi: 10.1002/ijc.32990.
6.Wang Quanxin#, Yang Jianling#, Qiu-Yue Qi, Li Bao, Xiao-Li Yang, Miao-Miao Liu, Pei Huang, Li-Xin Zhang, Ji-Long Chen*, Lei Cai*, Hong-Wei Liu*, 3-Anhydro-6- ydroxy-ophiobolin A, a new sesterterpene inhibiting the growth of methicillin-resistant Staphylococcus aureus and inducing the cell death by apoptosis on K562, from the phytopathogenic fungus Bipolaris oryzae. Bioorganic & Medicinal Chemistry Letters. 23(12): 3547-3550, 2013. (IF=3.5 co-first author)
7.Xuefei Wang, Jianling Yang, Guijie Guo, Riyue Feng, Lianfeng Zhang, Shile Huang, Ji- long Chen*, Novel lncRNA-IUR suppress Bcr-Abl-induced tumorigenesis through regulation of STAT5-CD71 pathway, Mol Cancer, 2019 Apr 8;18(1):84. (IF=41.4)
专利项目:
1.发明专利:陈吉龙,杨建岭,郭桂杰,陈玉海;小鼠白血病病毒转化骨髓细胞系的建立方法及其 应用。(专利号:ZL201110148806.1,公开号,CN102229960A)
2.发明专利:杨建岭,薛丽香,刘扬,杨得草,于佳卉;一种外泌体形式半乳糖凝集素 9 的检测方法与试剂盒(专利号:CN202211163591.5,公开号,CN115902204A)
3.发明专利:霍霄,薛丽香,杨建岭,郭正阳,黄架旗,宋佳桂,何天慧;基于多不饱和脂肪酸相关基因的卵巢癌预后风险模型及其制备方法和应用,(专利号:
CN202210622078.1,公开号,CN114807374A)