研究员，博士生导师

北京大学第三医院

血管稳态与重构全国重点实验室

yaohuaz@bjmu.edu.cn

张耀华，博士，北京大学第三医院研究员，血管稳态与重构全国重点实验室PI，内科学（心血管病）硕、博士研究生导师。博士毕业于中国医学科学院&北京协和医学院，在国家心血管病中心，心血管疾病国家重点实验室完成博士课题研究。先后在美国休斯顿健康医学中心和MD Anderson癌症中心从事博士后研究。入选2022年北京市海外高层次人才青年项目，获得2022年国家自然科学基金委海外优青项目资助。研究工作主要是基于多组学研究技术，探索蛋白翻译后修饰在心血管病发病中的作用机制。开发疾病评分和分层的生物标志物，辅助实现疾病的精准诊断，并开发针对疾病的精准干预策略。近五年以第一作者（含共同）和通讯作者在Science、Nature Cell Biology、Circulation、Science Translational Medicine等国际知名杂志发表高水平学术论文，累计影响因子超过200。

教育经历:

科研工作经历：

研究方向：

o 基于蛋白翻译后修饰的心力衰竭发病机制和诊断方法研究

o 冠心病诊断分层生物标志物和分子影像探针开发

o 蛋白新型翻译后修饰的研究和心血管疾病新型干预方式研发

Yaohua Zhang, PhD

Principle Investigator, Professor

State Key Laboratory of Vascular Homeostasis and Remodeling

Department of Cardiology and Institute of Vascular Medicine

Peking University Third Hospital

Peking University Health Science Center

yaohuaz@bjmu.edu.cn

Dr. Yaohua Zhang, a professor at Peking University Third Hospital, holds the position of Principal Investigator (PI) for the National Key Laboratory of Vascular Homeostasis and Remodeling. Before this, he conducted postdoctoral research at the University of Texas Health Science Center in Houston and the renowned MD Anderson Cancer Center in the United States. Acknowledged for his exceptional contributions, Dr. Zhang was honored with the 2022 Beijing Overseas High-level Talents Youth Program and received funding from the Science Fund Program for Excellent Young Scientists (Overseas) in the same year. His research endeavors primarily delve into the mechanisms behind post-translational protein modifications in cardiovascular diseases, leveraging multi-omics technology. His ultimate aim is to establish biomarkers for disease scoring and stratification, thereby enhancing the accuracy of diagnosis and precision in intervention strategies. In the past five years, he has led or contributed significantly to numerous highly influential academic publications in esteemed international journals such as Science, Nature Cell Biology, Circulation, and Science Translational Medicine, collectively achieving a cumulative impact factor surpassing 200.

Education

PhD, Biochemistry and Molecular Biology, Peking Union Medical College, 2013-2016

MS, Biochemistry and Molecular Biology, Shanxi University, 2009-2012

Bachelor of Management, Information Management and Information Systems, Shanxi Agricultural University, 2007-2009

Bachelor of Science, Biological Sciences, Shanxi Agricultural University, 2005-2009

Research Experiences

2023/10 to Current Associate professor, Peking University Third Hospital

2022/01-2023/10 Professor, Beijing Institute of Brain Diseases

2017/12 -2021/12 Postdoctoral research fellow, MD Anderson Cancer Center

2017/05 -2017/12 Postdoctoral research fellow, The University of Texas Health Science Center at Houston

2012/08-2013/06 Research Assistant, National Center for Cardiovascular Diseases

Research interests

o Research on the pathogenesis and diagnosis of heart failure based on protein post-translational modification

o Development of biomarkers and molecular imaging probes for stratification of coronary heart disease diagnosis

o Research on new protein post-translational modifications and development of new intervention methods for cardiovascular disease Drugs, gut microbiome, and cardiometabolic disease (CMD)

Publications

· Yaohua Zhang*, Zilong Zhao*, Lisa A Huang*, Yuan Liu, Jun Yao, Chengcao Sun, Yajuan Li, Zhao Zhang, Youqiong Ye, Fei Yuan, Tina K Nguyen, Nikhil Reddy Garlapati, Andrew Wu, Sergey D Egranov, Abigail S Caudle, Aysegul A Sahin, Bora Lim, Laura Beretta, George A Calin, Dihua Yu, Mien-Chie Hung, Michael A Curran, Katayoun Rezvani, Boyi Gan, Zhi Tan, Leng Han#, Chunru Lin#, Liuqing Yang#. Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation. Cell Metab. 2023 Jun 12: S1550-4131(23)00186-9. 第一作者(IF=29.01)

· Xu Han, Zihan Yan, Kaiyu Fan, Xueyi Guan, Bohan Hu, Xiang Li, Yunwei Ou, Bing Cui, Lingxuan An, Yaohua Zhang#, Jian Gong#. The combined signatures of telomere and immune cell landscape provide a prognostic and therapeutic biomarker in glioma. Front Immunol. 2023 Aug 17:14:1220100. 共同通讯作者 (IF=7.3)

· Yuru Zong, Xuliang Wang, Bing Cui, Xiaowei Xiong, Andrew Wu, Chunru Lin, Yaohua Zhang. Decoding the Regulatory Roles of Non-coding RNAs in Cellular Metabolism and Disease. Molecular Therapy. 2023 Apr 26; S1525-0016(23)00210-1. 通讯作者（IF=12.910）

· Yaohua Zhang*#, Chengcao Sun*, Yajuan Li*, Juan Qin*, Kaushik Amancherla, Ying Jing, Qingsong Hu, Ke Liang, Zhao Zhang, Youqiong Ye, Lisa A. Huang, Tina K. Nguyen, Sergey D. Egranov, Joe-Elie Salem, Douglas B. Johnson, Michael A. Curran, Dihua Yu, Leng Han, Radbod Darabi, Liuqing Yang#, Javid J. Moslehi#, Chunru Lin#. Hormonal Therapies Upregulate MANF and Overcome FemaleSusceptibility to Immune Checkpoint-Inhibitor (ICI)-Myocarditis. Sci Transl Med. 2022 Nov 2;14(669): eabo1981. (第一兼通讯作者) IF=19.319.

· Congxia Bai*, Ming Su*, Yaohua Zhang*, Yahui Lin*, Yingying Sun, Li Song, Ning Xiao, Haochen Xu, Hongyan Wen, Meng Zhang, Jiedan Ping, Jing Liu, Rutai Hui, Hao Li#, Jingzhou Chen#. Oviductal Glycoprotein 1Promotes Hypertension by Inducing Vascular Remodeling Through an Interaction with MYH9. Circulation. 2022 Sep 29: 101-161. IF=39.918. (共同第一作者)

· Yaohua Zhang, Yajuan Li, Qingsong Hu et al. The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin. Nat Cell Biol. 22,1332-1345 (2020). (第一作者) IF=28.213.

· Yajuan Li*, Zhi Tan*, Yaohua Zhang* et al. A noncoding RNA modulator potentiates phenylalanine metabolism in mice. Science. 2021;373(6555):662-673. (共同第一作者) IF=63.714.

· Yajuan Li*, Yaohua Zhang*, Qingsong Hu et al. Functional significance of gain-of-function H19 lncRNA in skeletal muscle differentiation and anti-obesity effects. Genome Med. 2021 Aug 28;13(1):137. (共同第一作者) IF=15.266.

· Qingsong Hu, Youqiong Ye, Li-Chuan Chan, Yaohua Zhang et al. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nat Immunol. 20, 835-851 (2019). IF=31.25.

· Ming-Ze Yao, Yao-Hua Zhang, Wen-Liang Lu, Miao-Qing Hu, Wei Wang, Ai-Hua Liang*. Phytases: Crystal Structures, Protein Engineering and Potential Biotechnological Applications. Journal of Applied Microbiology. 2012,112(1):1-14.

· Mingze Yao, Wenliang Lu, Yaohua Zhang, Ai-hua Liang*, Isolation and identification of two phytase-producing strains from soybean rhizosphere soil and cloning of neutral phytase gene. Food Science. 2012, 07(16).