科研工作
2004-2006年赴美国纽约西奈山医学院进行关于母胎界面免疫及感染相关性免疫的机制研究,回国后继续生殖免疫和母胎界面免疫调节,包括:脂氧素在受精卵着床及妊娠中的作用、微颗粒对妊娠免疫和炎症的调节作用及碳氢化合物受体AhR对妊娠免疫的调节,近年集中于着床期间内膜免疫微环境研究。作为项目负责人主持国自然科学基金四个,为国自然基金评审专家,发表SCI多篇。
学术兼职
中国康复医学会产后康复专业委员会第一届泌尿尿系统康复学组常务委员
中国女医师协会母胎医学专业委员会第一届委员会委员
获奖情况
重组人巨细胞病毒PP65蛋白与中药“金叶败毒颗粒”的联合抗人巨细胞病毒效应的研究;2003年云南省科技进步奖三等奖(第一获奖人)
“Foxp3+Treg在尖锐湿疣组织局部免疫抑制中的作用及低剂量的环磷酰胺治疗尖锐湿疣的临床应用”;2012年湖北省科技进步三等奖(第二获奖人)
“Foxp3+Treg在尖锐湿疣组织局部免疫抑制中的作用;2012年武汉市科技进步二等奖(第二获奖人)
妊娠生理与胎儿宫内发育;2012年第十二届全国多媒体课件大赛,高教医学组优秀奖(第一获奖人)
同济医院先进教师;2013年同济医院个人奖
论文
1.赖少阳、周旋、赵捷;妊娠过程中胎盘囊泡的发生发展及临床意义华中科技大学学报(医学版); 2019;48(4):233-236(通讯作者)
2.岳 静、王丽娜、杨蕊、杨纨、周旋、赖少阳、周罗绮、赵捷;多囊卵巢综合征患者血清HSP70、IMA水平的变化及与性激素和氧化应激的相关性研究;现代生物医学进展;2010;20(1):64-67(通讯作者)
3.Mei Han,Yuan Yao,Wanjiang Zeng,Yanfang Wang,Lin Feng,Jie zhao.Complexes of trophoblastic peptides and heat shock protein 70 as a novel contraceptive vaccine in a mouse model.Reprod Biomed Online. 2016;Apr;32(4):457-65 (通讯作者)影响因子:2.94
4.Jie zhao,wanjiang Zeng,Yuchun Cao,Xiaoyu Liang,Bo Huang. Immunotherapy of HPV infection-caused genital warts using low dose cyclophosphamide. Expert Rev Clin Immunol.2014;Jun;10(6):791-9(第一作者与通讯作者)影响因子:3.34.
5.Xu Z,Zhao J, Zhang H, Ke T, Xu P, Cai W, Katirai F, Ye D, Huang Y, Huang B.Spontaneous miscarriages are explained by the stress/glucocorticoid/lipoxin a4 axis.J Immunol. 2013 Jun 15;190(12):6051-8.(共同第一作者),影响因子:5.52分
6.Jie Zhao, Yuchun Cao, Zhang Lei, Zhuoshun yang, Biao Zhang, Bo Huang. Selective Depletion of CD4+CD25+Foxp3+ Regulatory T Cells by Low-Dose Cyclophosphamide Is Explained by Reduced Intracellular ATP Levels. Cancer Res. 2010;70(12):4850-8.影响因子:8.65分
7.Jie Zhao, Zhang Lei,Yanyan Liu, Bo Li, Liang Zhang, Haoshu Fang, Chuanwang Song, Xiaomei Wang, Gui-Mei Zhang, Zuo-Hua Feng, Bo Huang. Human Pregnancy Upregulates Tim-3 in Innate Immune Cells for Systemic Immunity. J Immunol. 2009;182(10):6618-24.影响因子:5.52分
8.Yuchun Cao*,Jie Zhao* (并列第一作者), Zhang Lei, Shiqian Shen, Cong Liu, Dong Li, Jihong Liu, Guan-Xing Shen, Gui-Mei Zhang, Zuo-Hua Feng, Bo Huang. Local accumulation of FOXP3+ regulatory T cells: evidence for an immune evasion mechanism in patients with large condylomata acuminata. J Immunol. 2008;180(11):7681-6.影响因子:5.52分
9.Jie Zhao, Hee Jeong Kong, Hongxing Li, Bo Huang, Ming Yang, Chun Zhu, Milena Bogunovic, Feng Zheng, Lloyd Mayer, Keiko Ozato, Jay C Unkeless, Huabao Xiong. IRF-8/ICSBP is involved in TLR signaling and contributes to the crosstalk between TLR and IFN-gamma signaling pathways. J Biol Chem, 2006;281(15):10073-80.(第一作者)影响因子:5.805分
10.Jing Liu,Jie Zhao, Yuchun Cao, Bo Huang. Low Dosages: new chemotherapeutic weapons on the battlefield of immune-related diseases. Cell Mol Immunol, 2011 Jul;8(4):289-95
11.Yuchun Cao,Jie Zhao, Zhuoshun Yang, Zaisheng Cai, Biao Zhang, Yu Zhou, Guan-Xin Shen, Xingping Chen, Shenqiu Li, Bo Huang. CD4+FOXP3+ regulatory T cell depletion by low-dose cyclophosphamide prevents recurrence in patients with large condylomata acuminata after laser therapy. Clin Immunol, 2010; 136(1):21-29
12. Huang B,Jie Zhao, Lei Z, Shen S, Li D, Shen GX, Zhang GM, Feng ZH. miR-142-3p restricts cAMP production in CD4(+)CD25(-) T cells and CD4(+)CD25(+) T(REG) cells by targeting AC9 mRNA. EMBO Rep. 2009;10(2):180-5.
13. Huang B,Jie Zhao, Unkeless JC, Feng ZH, Xiong H. TLR signaling by tumor and immune cells: a double-edged sword. Oncogene. 2008;27(2):218-24.
14. Bo Huang,Jie Zhao, Shiqian Shen, Hongxing Li, Kai-Li He, Guan-Xin Shen, Lloyd Mayer, Jay Unkeless, Dong Li, Ye Yuan, Gui-Mei Zhang, Huabao Xiong, Zuo-Hua Feng. Listeria monocytogenes promotes tumor growth via tumor cell TLR2 signaling. Cancer Res. 2007;67(9):4346-52.
15. Bo Huang,Jie Zhao, Hongxing Li, Kai-Li He, Yibang Chen, Shu-Hsia Chen, Lloyd Mayer, Jay C. Unkeless, Huabao Xiong. Toll like receptor(TLR) on tumor cells facilitate evasion of immune surveillance. Cancer Res. 2005, 65(12):5009-14
16.赵捷,闻良珍,陈素华等。金叶败毒颗粒对孕鼠免疫和生殖功能影响的研究,中成药,2003,25(2): 130-132
17.赵捷,闻良珍,陈素华等。人巨细胞病毒PP65蛋白基因的克隆及表达,中国优生与遗传杂志,2003,11(1):40-42
18.赵捷,闻良珍,陈素华等。人巨细胞病毒PP65蛋白原核表达载体构建及表达产物对特异性免疫应答的诱导,中华围产医学杂志,2003,6(2):109-112