医学博士学位，教授、主任医师，博士研究生导师，国务院政府特殊津贴获得者，国家卫生健康突出贡献中青年专家。

现任北京大学第三医院院长、党委副书记，肿瘤中心主任。

历任北京大学第三医院党委副书记兼纪委书记、副院长（主管医疗工作）。普通外科副主任、普通外科党支部书记、危重医学科主任、急诊部主任、机场院区院长。

长期从事胃肠外科的医疗、教学、科研和急危重症救治，致力于微创技术以及多学科诊疗模式的推广和应用，拓展和推进胃肠道肿瘤治疗的微创化和规范化。同时，基于在临床实践中发现的科学问题，积极开展基础和临床相结合的转化医学研究和跨学科的交叉融合研究，担任科技部重点研发计划项目首席科学家，北京市重点实验室主任，主持国家自然科学基金9项和省部级科学基金5项，多篇成果发表在Science、Cancer Cell、Gut、Cell Discovery等学术期刊。

学协会及学术任职

北京医师协会理事会副会长

北京抗癌协会副理事长

北京医院协会监事长

北京医学会常务理事

《中国微创外科杂志》编辑部主任

《中华普通外科杂志》编委

《中华外科杂志》编委

《Malignancy Spectrum》副主编

获奖情况

2020年9月，获“北京市抗击新冠肺炎疫情先进个人”称号

2020年，被中共北京市委表彰为“北京市优秀共产党员”

2020年，获评“2020年度全国改善医疗服务创新型院长”

2021年，获“国务院政府特殊津贴”

2023年，获评国家卫生健康突出贡献中青年专家

2024年，获评北京市教育系统教书育人先锋

论文

[1]Emerging neuroimmune mechanisms in cancer neuroscience, Cancer Letters, 2025, 612:217492

[2]Neurodegeneration of local sympathetic inputs promotes colorectal cancer progression, Cancer Letters, 2025, 625:217817

[3]Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression, Cell Metabolism, 2025, 37(9): 1852-1869.e8

[4]A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH, Cell Metabolism, 2024, 36(8): 1823-1838

[5]Single-cell chromatin accessibility analysis reveals the epigenetic basis and signature transcription factors for the molecular subtypes of colorectal cancers, Cancer Discovery, 2024, 14(6):1082-1105

[6]Measuring distance from lowest boundary of rectal tumor to anal verge on CT images using pyramid attention pooling transformer, Computers in Biology and Medicine, 2023;155: 106675

[7]Integrative single-cell multiomics analyses dissect molecular signatures of intratumoral heterogeneities and differentiation states of human gastric cancer, National Science Review, 2023,10(6):nwad094

[8]Role of the gut microbiota and its metabolites in tumorigenesis or development of colorectal cancer, Advanced Science, 2023, 10(23):e2205563

[9]Relationships of tumor differentiation and immune infiltration in gastric cancers revealed by single-cell RNA-seq analyses, Cellular and Molecular Life Sciences, 2023, 80(2):57

[10]Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids, Protein&Cell, 2023, 15(4): 285-304

[11]Impact of body composition during neoadjuvant chemoradiotherapy on complications, survival and tumor response in patients with locally advanced rectal cancer, Frontiers in Nutrition, 2022, 9: 36

[12]Expression signature of the AT-rich interactive domain gene family identified in digestive cancer, Frontiers in Medicine, 2022, 8: 775357

[13]Single-cell profiling reveals molecular basis of malignant phenotypes and tumor microenvironments in small bowel adenocarcinomas, Cell Discovery, 2022, 8(1): 92

[14]Increasing burden of colorectal cancer in China, The Lancet Gastroenterology & Hepatology, 2022, 7(8): 700

[15]Genome-scale methylation analysis of circulating cell-free DNA in gastric cancer patients, Clinical Chemistry, 2022, 68(2): 354-364

[16]Establishment and characterization of adult human gastric epithelial progenitor‐like cell lines, Cell Proliferation, 2022, 56(6): e13355

[17]Systematic evaluation of colorectal cancer organoid system by single-cell RNA-Seq analysis, Genome Biology, 2022, 23(1): 106

[18]A glycolysis-related two-gene risk model that can effectively predict the prognosis of patients with rectal cancer, Human Genomics, 2022, 16(1): 1-17

[19]Spatially resolved expression landscape and gene-regulatory network of human gastric corpus epithelium, Protein & Cell, 2023, 14(6): 433-447

[20]Single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer tumors, Genome Medicine, 2022, 14(1): 1-26.

[21]Progress in the study of colorectal cancer caused by altered gut microbiota after cholecystectomy, Frontiers in Endocrinology, 2022, 13: 815999

[22]Long non-coding RNA profile study identifies a metabolism-related signature for colorectal cancer, Molecular Medicine, 2021, 27(1): 1-13

[23]High CFP score indicates poor prognosis and chemoradiotherapy response in LARC patients, Cancer Cell International, 2021, 21(1): 1-11

[24]Comparison of the sigmoid take-off with other definitions of the rectosigmoid junction: A retrospective comparative cohort analysis, International Journal of Surgery, 2020, 80: 168-174

[25]Characteristic analysis of featured genes associated with stemness indices in colorectal cancer, Frontiers in Molecular Biosciences, 2020, 7: 563922

[26]Genomic and transcriptomic profiling of carcinogenesis in patients with familial adenomatous polyposis, Gut, 2020, 69(7): 1283-1293

[27]Single-cell multiomics sequencing reveals prevalent genomic alterations in tumor stromal cells of human colorectal cancer, Cancer Cell, 2020, 38(6): 818-828. e5

[28]Detection of colorectal cancer in circulating cell-free DNA by methylated CpG tandem amplification and sequencing, Clinical Chemistry, 2019, 65(7): 916-926.

[29]Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine, Journal of Experimental Medicine, 2019, 217(2): e20191130.

[30]TGF-β signaling regulates DACT1 expression in intestinal epithelial cells, Biomedicine & Pharmacotherapy, 2018, 97: 864-869.

[31]Single-cell multiomics sequencing and analyses of human colorectal cancer, Science, 2018, 362(6418): 1060-1063

著作与译著

[1] 《奈特胃肠病学》第三版（北京大学医学出版社，2023）

[2] 《外科学》 （北京大学医学出版社，2020）

[3] 《腹腔镜手术的发展与争议》（人民卫生出版社，2007）

[4] 《直肠肛门部恶性肿瘤》 （北京大学医学出版社，2007）

[5] 《外科疾病决策流程》 （人民卫生出版社，2006）

[6] 《结肠直肠外科手术图谱》 （辽宁教育出版社，1999）

[7] 《胃肠外科学》 （辽宁教育出版社，1999）

[8] 《普外腹腔镜手术学》 （人民卫生出版社，1998）