中共党员，研究生学历、医学博士学位，教授、主任医师，博士研究生导师，国务院政府特殊津贴获得者，国家卫生健康突出贡献中青年专家。

现任北京大学第三医院院长、党委副书记，肿瘤中心主任、罕见病诊治中心主任

历任北京大学第三医院党委副书记兼纪委书记、副院长（主管医疗工作）。普通外科副主任、普通外科党支部书记、危重医学科主任、急诊部主任、机场院区院长。

长期从事胃肠外科的医疗、教学、科研和急危重症救治，致力于微创技术以及多学科诊疗模式的推广和应用，拓展和推进胃肠道肿瘤治疗的微创化和规范化。同时，基于在临床实践中发现的科学问题，积极开展基础和临床相结合的转化医学研究和跨学科的交叉融合研究，主持科技部重点研发计划项目1项、国家自然科学基金7项和省部级科学基金4项，多篇成果发表在Science、Cancer Cell、Gut、Cell Discovery等学术期刊。

学术兼职

北京抗癌协会副理事长

中国质量协会医疗与健康分会副会长

中国老年保健医学研究会理事

中国医疗保健国际交流促进会胃肠外科分会副主任委员

中国医师协会外科医师分会结直肠外科医师委员会常委

中华医学会外科学分会实验外科与转化医学组委员

中华医学会外科学分会－内分泌外科学组委员（第一届）

获奖情况

2020年9月，获“北京市抗击新冠肺炎疫情先进个人”称号

2020年9月30日，被中共北京市委表彰为“北京市优秀共产党员”

2020年12月26日，获评“2020年度全国改善医疗服务创新型院长”

2021年，获“国务院政府特殊津贴”

2023年，获评国家卫生健康突出贡献中青年专家

论文

1. Dong J, Wu X, Zhou X, Gao Y, Wang C, Wang W, He W, Li J, Deng W, Liao J, Wu X, Lu Y, Chen AK, Wen L, Fu W*, Tang F* (2023) Spatially resolved expression landscape and gene-regulatory network of human gastric corpus epithelium. Protein Cell 14: 433-447

2. Gao Y, Dong J, Qi S, Zhou X, Wu X, Wang W, Wen L, Fu W*, Tang F* (2023) Establishment and characterization of adult human gastric epithelial progenitor-like cell lines. Cell Prolif 56(6):e13355

3. Zhou X, Yang J, Lu Y, Ma Y, Meng Y, Li Q, Gao J, Jiang Z, Guo L, Wang W, Liu Y, Wen L, Kai M, Fu W*, Tang F* (2023) Relationships of tumor differentiation and immune infiltration in gastric cancers revealed by single-cell RNA-seq analyses. Cell Mol Life Sci 80: 57

4. Mao Y, Wang W, Yang J, Zhou X, Lu Y, Gao J, Wang X, Wen L, Fu W*, Tang F* (2023) Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids. Protein Cell Jun 22;pwad038

5. Qu R, Zhang Y, Ma Y, Zhou X, Sun L, Jiang C*, Zhang Z*, Fu W* (2023) Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer. Adv Sci (Weinh): e2205563

6. Yang J, Zhou X, Dong J, Wang W, Lu Y, Gao Y, Zhang Y, Mao Y, Gao J, Wang W, Li Q, Gao S, Wen L, Fu W*, Tang F* (2022) Single-cell profiling reveals molecular basis of malignant phenotypes and tumor microenvironments in small bowel adenocarcinomas. Cell Discovery 8: 92

7. Wang R, Li J, Zhou X, Mao Y, Wang W, Gao S, Wang W, Gao Y, Chen K, Yu S, Wu X, Wen L, Ge H, Fu W*, Tang F* (2022) Single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer tumors. Genome Med 14: 93

8. Wang R, Mao Y, Wang W, Zhou X, Wang W, Gao S, Li J, Wen L, Fu W*, Tang F* (2022) Systematic evaluation of colorectal cancer organoid system by single-cell RNA-Seq analysis. Genome Biol 23: 106

9. Qu R, Ma Y, Zhang Z*, Fu W* (2022) Increasing burden of colorectal cancer in China. Lancet Gastroenterol Hepatol 7: 700

10. Ren J, Lu P, Zhou X, Liao Y, Liu X, Li J, Wang W, Wang J, Wen L, Fu W*, Tang F* (2022) Genome-Scale Methylation Analysis of Circulating Cell-Free DNA in Gastric Cancer Patients. Clin Chem 68(2):354-364

11. Zhou Y, Bian S, Zhou X, Cui Y, Wang W, Wen L, Guo L, Fu W*, Tang F* (2020) Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer. Cancer Cell 38(6):818-828

12. Wang Y, Song W, Wang J, Wang T, Xiong X, Qi Z, Fu W*, Yang X*, Chen YG* (2020) Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine. J Exp Med 217

13. Li F, Wang B, Lu S, Wang Y, Sun T, Wang H, Zhou X*, Fu W* (2020) Comparison of the sigmoid take-off with other definitions of the rectosigmoid junction: A retrospective comparative cohort analysis. Int J Surg 80:168-174

14. Li F, Zhou X, Wang B, Guo L, Ma Y, Wang D, Wang L, Zhang L, Wang H, Zhang L, Tian M, Tao M, Xiu D, Fu W (2019) Intestinal Perforation Secondary to Pits of Jujube Ingestion: A Single-Center Experience with 18 Cases. World J Surg 43(5):1198-1206

15. Li J, Wang R, Zhou X, Wang W, Gao S, Mao Y, Wu X, Guo L, Liu H, Wen L, Fu W*, Tang F* (2019) Genomic and transcriptomic profiling of carcinogenesis in patients with familial adenomatous polyposis. Gut 69(7):1283-1293

16. Bian S, Hou Y, Zhou X, Li X, Yong J, Wang Y, Wang W, Yan J, Hu B, Guo H, Wang J, Gao S, Mao Y, Dong J, Zhu P, Xiu D, Yan L, Wen L, Qiao J*, Tang F*, Fu W* (2018) Single-cell multiomics sequencing and analyses of human colorectal cancer. Science 362: 1060-1063

17. Li F, Zhou X, Wang B, Guo L, Wang J, Wang W, Fu W (2017) Comparison between different approaches applied in laparoscopic right hemi-colectomy: A systematic review and network meta-analysis. Int J Surg 48: 74-82

18. Zhou X, Wang B, Li F, Wang J, Fu W (2017) Risk Factors Associated With Nonclosure of Defunctioning Stomas After Sphincter-Preserving Low Anterior Resection of Rectal Cancer: A Meta-Analysis. Dis Colon Rectum 60: 544-554

19. Zhou X, Xie H, Xie L, Li J, Cao W, Fu W (2014) Endoscopic resection therapies for rectal neuroendocrine tumors: a systematic review and meta-analysis. J Gastroenterol Hepatol 29: 259-68

20. Zhou X, Xie H, Xie L, Li J, Fu W (2013) Factors associated with lymph node metastasis in radically resected rectal carcinoids: a systematic review and meta-analysis. J Gastrointest Surg 17: 1689-97

21. Ren L, Upadhyay AM, Wang L, Li L, Lu J, Fu W (2009) Mortality rate prediction by Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity (POSSUM), Portsmouth POSSUM and Colorectal POSSUM and the development of new scoring systems in Chinese colorectal cancer patients. Am J Surg 198: 31-8

著作与译著

《普外腹腔镜手术学》 （人民卫生出版社，1998）

《结肠直肠外科手术图谱》 （辽宁教育出版社，1999）

《胃肠外科学》 （辽宁教育出版社，1999）

《外科疾病决策流程》 （人民卫生出版社，2006）

《腹腔镜手术的发展与争议》（人民卫生出版社，2007）

《直肠肛门部恶性肿瘤》 （北京大学医学出版社，2007）

《外科学》 （北京大学医学出版社，2020）

《奈特胃肠病学》第三版（北京大学医学出版社，2023）