刘承

基本情况

姓名:刘承性别:男
学位:博士 毕业院校:瑞典卡洛琳斯卡医学院(Karolinska Institutet)
专业:泌尿外科,泌尿系肿瘤 技术职称:副主任医师 副教授
导师资格:博士生导师

专业特长

专注于前列腺癌等泌尿系统肿瘤的诊断与治疗。长期从事泌尿系统肿瘤的临床与学术工作,具有丰富的临床经验,洞悉国内外肿瘤治疗的前沿,熟练开展复杂泌尿外科手术,尤其擅长腹腔镜及其他微创泌尿外科手术。多次在美国泌尿外科年会、欧洲泌尿外科年会上进行学术报告,并应邀在国内各学术会议上进行手术演示或大会发言。特别强调注重针对不同患者具体情况的个体化治疗和国内外最新治疗方案的综合应用。

科研工作

  研究方向:前列腺癌等泌尿系统肿瘤

主持国家级泌尿系统肿瘤研究项目4项(包括国家自然科学基金面上项目2项,国际合作项目1项),主持省部级研究基金多项。参与国家973重点项目一项。其领导的研究团队两次在国际顶尖肿瘤学刊物Journal of the National Cancer Institute(JNCI发表研究成果,在前列腺癌等泌尿系统肿瘤研究领域具有较大影响。同时还在Cancer Research,Journal of Pathology等国际著名学术刊物发表研究论文20多篇。

学术兼职

中华医学会泌尿外科分会 全国青年委员

北京市肿瘤学会临床研究委员会委员

北京医学会泌尿外科分会基础与转化医学学组副组长

获奖情况

山东省科技进步二等奖(2012年)、山东省高等学校优秀科研成果奖(2014年)

著作与译注

1.主译:临床笔记:泌尿外科学(第六版)(山东科技出版社) 2.Liu L, Liu C, Fotouhi O, Fan Y, Wang K, Xia C, Shi B, Zhang G, Wang K, Kong F, Larsson C, Hu S, Xu D. TERT Promoter Hypermethylation in Gastrointestinal Cancer: A Potential Stool Biomarker. Oncologist. 2017 Oct;22(10):1178-1188. 3.Yuan X, Liu C, Wang K, Liu L, Liu T, Ge N, Kong F, Yang L, Bj?rkholm M, Fan Y, Zhao S, Xu D. The genetic difference between Western and Chinese urothelial cell carcinomas: infrequent FGFR3 mutation in Han Chinese patients. Oncotarget. 2016 ,7(18):25826-35. 4.Wang K, Liu T, Liu C, Meng Y, Yuan X, Liu L, Ge N, Liu J, Wang C, Ren H, Yan K, Hu S, Xu Z, Fan YD*, Xu D.TERT promoter mutations and TERT mRNA but not FGFR3 mutations are urinary biomarkers in Han Chinese patients with urothelial bladder cancer. Oncologist. 2015,20(3):263-9. 5.Wang K, Liu T, Ge N, Liu L, Yuan X, Liu J, Kong F, Wang C, Ren H, Yan K, Hu S, Xu Z, Bj?rkholm M, Fan Y, Zhao S, Liu C, Xu D.TERT promoter mutations are associated with distant metastases in upper tract urothelial carcinomas and serve as urinary biomarkers detected by a sensitive castPCR.Oncotarget. 2014 Dec 15;5(23):12428-39. 6.Han H, Xu D, Liu C, Claesson HE, Bj?rkholm M, Sj?berg J. Interleukin-4-mediated 15-lipoxygenase-1 trans-activation requires UTX recruitment and H3K27me3 demethylation at the promoter in A549 cells. PLoS One. 2014 Jan 20;9(1):e85085. 7.Wang K, Liu T, Liu L, Liu J, Liu C, Wang C, Ge N, Ren H, Yan K, Hu S, Bj?rkholm M, Fan Y, Xu D.TERT promoter mutations in renal cell carcinomas and upper tract urothelial carcinomas. Oncotarget. 2014 Apr 15;5(7):1829-36. 8.Liu C, Wang C, Wang K, Liu L, Shen Q, Yan K, Sun X, Chen J, Liu J, Ren H, Liu H, Xu Z, Hu S, Xu D, Fan YD.SMYD3 as an oncogenic driver in prostate cancer by stimulation of androgen receptor transcription. J Natl Cancer Inst. 2013,105(22):1719-28. 9.Yan K, Liu C, Xu Z, Liu Z, Wang K, Jiang Y, Fan YD.Renal cell carcinoma presenting as exfoliative dermatitis (erythroderma) - a case report. Clin Nephrol. 2013,80(1):63-6. 10.Liu C, Schain F, Han H, Xu D, Andersson-Sand H, Forsell P, Claesson HE, Bj?rkholm M, Sj?berg J .Epigenetic and transcriptional control of the 15-lipoxygenase-1 gene in a Hodgkin lymphoma cell line, Exp Cell Res. 2012, 318(3):169-76. 11.Liu C, Xu D, Han H, Fan Y, Schain F, Xu Z, Claesson HE, Bj?rkholm M, Sj?berg J. Transcriptional Regulation of 15-Lipoxygenase Expression by Histone H3 Lysine 4 Methylation/Demethylation. PLoS One. 2012;7(12):e52703. 12.Liu L, Liu C, Lou F, Zhang G, Wang X, Fan Y, Yan K, Wang K, Xu Z, Hu S, Bj?rkholm M, Xu D*. Activation of telomerase by seminal plasma in malignant and normal cervical epithelial cells. J Pathol. 2011,225(2):203-211. 13.Ge Z, Li W, Wang N, Liu C, Zhu Q, Bj?rkholm M, Gruber A, Xu D. Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase. FASEB J. 2010 Feb;24(2):579-86. 14.Str??t K, Liu C, Rahbar A, Zhu Q, Liu L, Wolmer-Solberg N, Lou F, Liu Z, Shen J, Jia J, Kyo S, Bj?rkholm M, Sj?berg J, S?derberg-Nauclér C, Xu D*. Activation of Telomerase by Human Cytomegalovirus,J Natl Cancer Inst. 2009, 101(7):488-97 15.Liu C, Xu D, Liu L, Schain F, Brunnstr?m A, Bj?rkholm M, Claesson HE, Sj?berg J. 15-Lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2009, 297(1):L196-203. 16.刘承,徐忠华. 机器人辅助下腹腔镜泌尿外科手术, 《腹腔镜外科杂志》, 2009, 14(2):157-159. 17.Zhu Q, Liu C, Ge Z, Fang X, Zhang X, Str??t K, Bj?rkholm M, Xu D*. Lysine-specific demethylase 1 (LSD1) Is required for the transcriptional repression of the telomerase reverse transcriptase (hTERT) gene, PLoS One. 2008, 16;3(1):e1446. 18.Differential expression of cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in non-Hodgkin lymphomas. Schain F, Schain D, Mahshid Y, Liu C, Porwit A, Xu D, Claesson HE, Sundstr?m C, Bj?rkholm M, Sj?berg J. Clin Lymphoma Myeloma. 2008 Dec;8(6):340-7. 19.Liu C, Fang X, Ge Z, Jalink M, Kyo S, Bj?rkholm M, Gruber A, Sj?berg J, Xu D*. The telomerase reverse transcriptase (hTERT) gene is a direct target of the histone methyltransferase SMYD3, Cancer Ressarch. 2007 ,67(6):2626-31. 20.Jalink M, Ge Z, Liu C, Bj?rkholm M, Gruber A, Xu D. Human normal T lymphocytes and lymphoid cell lines do express alternative splicing variants of human telomerase reverse transcriptase (hTERT) mRNA. Biochem Biophys Res Commun. 2007 Feb 23;353(4):999-1003. 21.Ge Z, Liu C, Bj?rkholm M, Gruber A, Xu D.Mitogen-activated protein kinase cascade-mediated histone H3 phosphorylation is critical for telomerase reverse transcriptase expression/telomerase activation induced by proliferation. Mol Cell Biol. 2006 Jan;26(1):230-7. 22.Chen F, Liu C, Lindvall C, Xu D, Ernberg I. Int J Cancer.Epstein-Barr virus latent membrane 2A (LMP2A) down-regulates telomerase reverse transcriptase (hTERT) in epithelial cell lines. 2005 Jan 10;113(2):284-9. 23.Liu C, Xu D, Sj?berg J, Forsell P, Bj?rkholm M, Claesson H. Transcriptional regulation of 15-lipoxygenase expression by promoter methylation. Exp Cell Res. 2004 , 297(1):61-7. 24.Zhang A, Wang J, Zheng B, Fang X, Angstr?m T, Liu C, Li X, Erlandsson F, Bj?rkholm M, Nordenskj?rd M, Gruber A, Wallin KL, Xu D.Telomere attrition predominantly occurs in precursor lesions during in vivo carcinogenic process of the uterine cervix. Oncogene. 2004 Sep 23;23(44):7441-7. 25.Liu C, Xu D. Inhibition of histone deacetylases. Methods Mol Biol. 2004;287:87-97.