工作经历

2017.8-至今 北京大学第三医院泌尿外科/男科

科研工作

十四五国家重点研发计划青年首席科学家，国家优青，博士生导师，博士后合作导师。聚焦于男性不育发病机制及临床诊治新策略，阐明多种导致无精子症的致病基因，克氏综合征、Y染色体微缺失、隐睾、特发性无精子症等NOA的发病机制及新型治疗方法，研究成果以第一或通讯作者身份发表论文三十余篇，获批国家发明专利3项，参加制订不育指南专家共识3项。

2025.10-2027.09 科技部国家重点研发计划（项目编号：2025YFC2708100）项目负责人

2023.01-2026.12国家自然科学基金面上项目（项目编号：82271634）项目负责人

2022.12-2025.12科技部国家重点研发计划（项目编号：2022YFC2702600）项目骨干

2022.01-2024.12北京市自然科学基金面上项目（项目编号：7222208）项目负责人

2020.01-2022.12 国家自然科学基金青年项目（项目编号：81901535）项目负责人

2020.01-2022.12 北京大学第三医院临床重点专项人才项目C类（项目编号：BYSYZD2019033） 项目负责人

2019.01-2020.12 北京市自然科学基金青年项目（项目编号：7194333）项目负责人

学术兼职

中国性学会健康大数据分会副主任委员

中国性学会男性生殖医学分会 副主任委员

中华预防医学会生育力保护分会 委员

中国细胞生物学学会生殖细胞生物学分会 委员

获奖情况

2022年华夏医学科技奖二等奖.

2021年全国妇幼健康科学技术奖，自然科学奖一等奖，

2020年教育部高等学校研究优秀成果奖（科学技术）二等奖.

2018年北京医学科技奖，二等奖，

2018年北京医学科技奖医学科普奖

2017年第 42 届美国男科学年会（American Society of Andrology），Lalor Foundation International Travel Award

论文

[1]  Zhao Q*, Fang Z*, Wang P*, Qian Z, Yang Y, Ran L, Zheng J, Tang Y, Cui X, Li YY#, Zhang Z#, Jiang H#. Polylactic Acid Micro/Nanoplastic Exposure Induces Male Reproductive Toxicity by Disrupting Spermatogenesis and Mitochondrial Dysfunction in Mice. ACS Nano. 2025 Feb 11;19(5):5589-5603.

[2]  Xi Y*, Gong C*, Zhang Z*, Zhu F*, Zhang Y, Tang Y, Yan L, Jiang H#, Qiao J#, Liu Q#. NAE1-mediated neddylation coordinates ubiquitination regulation of meiotic recombination during spermatogenesis. Theranostics. 2025 Feb 10;15(7):3122-3142.

[3]  Wang X*, Liu Q*, Zhuang Z*, Cheng J, Zhang W, Jiang Q, Guo Y, Li R, Lu X, Cui L, Weng J, Tang Y, Yue J, Gao S, Hong K, Qiao J, Jiang H#, Guo J#, Zhang Z#. Decoding the pathogenesis of spermatogenic failure in cryptorchidism through single-cell transcriptomic profiling. Cell Rep Med. 2024 Sep 17;5(9):101709.

[4]  Liu T*, Cao Y*, Weng J, Gao S, Jin Z, Zhang Y, Yang Y, Zhang H, Xia C, Yin X, Luo Y, He Q, Jiang H#, Wang L#, Zhang Z#. Hepatitis E virus infects human testicular tissue and Sertoli cells. Emerg Microbes Infect. 2024 Dec;13(1):2332657.

[5]  Li C*, Wang Y*, Mu R*, Zhao J, Yao Z, Zhai J, Jin Y, Liu R, Liu D, Hong K, Jiang H#, Zhang Z#. Urate-lowering agents do not have clinically relevant negative effects on sperm quality and reproductive hormones in men with gout: a prospective open-label cohort study. Rheumatol Int. 2024 Jul;44(7):1245-1253.

[6]  Zhang Z.*, Xi Y.*, Liu D.-F., Mao J.-M., Zhang H.-T., Lin H.-C., Tang W.-H., Jiang H., Hong K., and Zhao L.-M#. Sperm retrieval outcomes of contralateral testis in men with nonobstructive azoospermia and unsuccessful unilateral microdissection testicular sperm extraction. Fertility and Sterility. 2024;121(3):540-542.

[7]  Xi Y.*, Cao Y.L.*, Tao L.Y., Gao S.Z., Jin Z.R., Cheng J.X., Jiang H.#, and Zhang Z#. A global perspective: characteristics of infertility‐related randomized clinical trials. Andrology. 2024: 12(6):1324-1335.

[8]  Jin Z.*, Cao Y.*, Wen Q.*, Zhang H., Fang Z., Zhao Q., Xi Y., Luo Z., Jiang H.#, Zhang Z.#, and Hang J#. Dapagliflozin ameliorates diabetes-induced spermatogenic dysfunction by modulating the adenosine metabolism along the gut microbiota-testis axis. Scientific Reports. 2024;14(1):641.

[9]  Jiang Y.*, Yang J.*, Xia L.*, Wei T., Cui X., Wang D., Jin Z., Lin X., Li F., and Yang K., Lang S., Liu Y., Hang J., Zhang Z.#, Hong T.#, Wei R#. Gut microbiota–tryptophan metabolism–GLP-1 axis participates in β-cell regeneration induced by dapagliflozin. Diabetes. 2024;73(6):926-940.

[10]  Cao Y.*, Jin Z.*, Xi Y., Cheng J., Fang Z., Zhao Q., Weng J., Zhu J., Tang Y., Zhang Z.#, and Jiang H#. Roles of ferroptosis in type 1 diabetes induced spermatogenic dysfunction. Free Radic Biol Med. 2024;214:193-205.

[11]  Zhao Q.C.*, Zhang Z.*, Zhao L.M.*, Deng Z.F., Gao J.M., Zhang H.L., Lin H.C., Liu D.F., Mao J.M., Zhang H.T., Chen Y.L., Tang W.H., and Jiang H#. A retrospective cohort study of geographic differences in the semen of 1,012 sperm donors in China. Transl Androl Urol. 2023;12(2):187-196.

[12]  Zhao Q.*, Zhu L., Weng J., Jin Z., Cao Y., Jiang H.#, and Zhang Z#. Detection and characterization of microplastics in the human testis and semen. Sci Total Environ. 2023;877:162713.

[13]  Zhang Z.*, Yang Y.-Z., Zhang H.-T., Xi Y., Wang C.-T., Liu D.-F., Mao J.-M., Lin H.-C., Tang W.-H., Zhao L.-M., Zhang X.-S.#, Dai Y.-T.#, and Jiang H#. Psychological status of infertile men during the Coronavirus Disease 2019 Pandemic in China: a cross-sectional investigation. Basic and Clinical Andrology. 2023;33(1):8.

[14]  Zhang Z.*, Hu J.*, Xiao S., Cao Y., Chen Y., Weng J., Jiang H.#, Li W.#, Chen J.-Y.#, and Liu C#. Microhomology-mediated circular DNA formation from oligonucleosomal fragments during spermatogenesis. eLife. 2023;12:RP87115.

[15]  Xu W.*#, Liu C.*, Zhang Z.*, Sun C., Li Q., Li K., Jiang H.#, Li W.#, and Sun Q#. DEtail-seq is an ultra-efficient and convenient method for meiotic DNA break profiling in multiple organisms. Sci China Life Sci. 2023;66(6):1392-1407.

[16]  Lu X.*, Luo Y.*, Nie X.*, Zhang B., Wang X., Li R., Liu G., Zhou Q., Liu Z., Fan L., Hotaling J.M., Zhang Z.#, Bo H.#, and Guo J#. Single-cell multi-omics analysis of human testicular germ cell tumor reveals its molecular features and microenvironment. Nat Commun. 2023;14(1):8462.

[17]  Jin Z.*, Yang Y.*, Cao Y.*, Wen Q., Xi Y., Cheng J., Zhao Q., Weng J., Hong K., Jiang H.#, Hang J.#, and Zhang Z#. The gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis. Microbiome. 2023;11(1):212.

[18]  Cao Y.*, Wang H.*, Jin Z.*, Hang J., Jiang H.#, Wu H.#, and Zhang Z#. Characterization of Non-Obstructive Azoospermia in Men Using Gut Microbial Profiling. J Clin Med. 2023;12(2):701.

[19]  Zhang Z.*, Wu H.*, Zheng L., Zhang H.-T., Yang Y.-Z., Mao J.-M., Liu D.-F., and Zhao L.-M., Liang H.#, Jiang H#. Identification and characterization of circular RNAs in the testicular tissue of patients with non-obstructive azoospermia. Asian Journal of Andrology. 2022;24(6):660-665.

[20]  Wang L(#), Zhang Z(#), Shu J(#), Zhang H, Yang Y, Liang Z, He Q, Huang W, Wang Y, Zhuang H, Jiang H(*), Wang L(*). Absence of hepatitis E virus RNA in semen samples of infertile male in China. Gut. 2020 Jul;69(7): 1363-1364.