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于洋研究员

发布时间:2023-09-07    点击数:

2B6BC

研究员,博士研究生导师

临床干细胞研究中心主任

生殖内分泌与辅助生殖技术北京市重点实验室副主任

国家杰出青年基金获得者

国家重点研发计划项目负责人

北京市优秀青年人才,北京市科技新星

基本情况

北京大学教授,北京大学第三医院研究员,临床干细胞研究中心主任,北京市生殖内分泌与辅助生殖技术重点实验室副主任,辅助生殖工程研究组组长,博士研究生导师。获得国家自然科学基金杰出青年基金,入选北京市优秀青年人才,北京市科技新星培养计划。近年来一直从事生殖及生殖相关障碍性疾病机理解析与治疗新策略的基础与应用基础研究工作。国家重点研发计划项目首席科学家,先后承担国家级科研项目10项,省部级科研项目4项。在相关领域的SCI期刊发表114篇论文,以第一或通讯作者在SCI期刊发表研究论文75篇,包括Cell,Cell Discovery,Nature Communications,Human Reproduction Update等,引用次数超过3500次,其中在Cell和Stem Cell Reports杂志发表的研究成果被选为cover story,入选ESI高被引论文,在国际国内学术会议做学术报告50余次。获批国家发明专利3项,实用新型专利1项,国际发明专利2项,科技成果转化1项。研究成果获得2013年华夏医学科技奖二等奖,2015年北京市科学技术奖一等奖,2016年华夏医学科技奖一等奖,2017年国家科技进步二等奖,2018年中华医学科技奖一等奖,2018美国米尔斯坦亚美(MMAAP)基金会医学奖。作为主编和副主编出版《Reproduction and the Inflammatory Response》和《生育力保护与生殖储备》等著作,其所在丛书获得第五届中华优秀出版物(图书)奖。目前担任国际SCI学术期刊Frontiers in Cell and Developmental Biology 副主编,国家核心期刊《天津医药》通讯编委,中华医学会疼痛学分会基础学组委员,中国老年学和老年医学学会抗衰老分会委员。

个人荣誉与奖励

  • 美国米尔斯坦亚美基金会2018 Fellowship Award,国际

  • 北京市优秀青年人才 2014年 北京市政府,省部级

  • 北京市科技新星 2014年 北京市科学技术委员会,省部级

  • 优秀博士论文 2010年 中国科学院,省部级

  • 院长优秀奖 2009年 中国科学院,省部级

  • 优秀博士毕业生 2009年 中国科学院,省部级

项目获奖

  • 中华医学科技奖,一等奖,排名第七,2018年,中华医学会,省部级

  • 国家科技进步奖,二等奖,排名第五,2017年,国务院,国家级

  • 华夏医学科技奖,一等奖,排名第六,2016年,中国医疗保健国际交流促进会,行业协会

  • 北京市科学技术进步奖,一等奖,排名第七,2015年,北京市政府,省部级

  • 华夏医学科技奖,二等奖,排名第二,2013年,中国医疗保健国际交流促进会,行业协会

     

  • 代表论文(影响因子均按照发表当年计算)
  1. Ke Zhong, Yu-Xin Luo, Dan Li, Zhe-Ying Min*, Yong Fan* , Yang Yu*. Generation of blastoids from human parthenogenetic stem cells. Life Medicine. 2023 In Press.

  2. Yu-Xin Luo, Yang Yu*. Protocol for the Generation of Human EPS-Blastoids Using a Three-Dimensional Two-Step Induction System. Methods Mol Biol. 2023 Feb 8. doi: 10.1007/7651_2022_471.

  3. Ye Wei, Miaochun Xu, Xiaoyu Liu, Shitong Lin, Wendi Pei, Ping Zhou, He Liu, Peng Wu*, Yang Yu*, Canhui Cao*. Single-cell transcriptome analysis of the mouse and primate ovaries reveals oocyte-specific expression patterns of risk genes in ovarian aging. MedComm. 2023 Feb 16;4(2):e209.

  4. Ping Zhou, Feng Deng, Zi Yang, Canhui Cao, Hongcui Zhao, Fenting Liu, Ke Zhong, Lin Fu, Tianliu Peng, Di Sun, Hui Liu, Rong Li, Yang Yu*. Ginsenoside Rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction. Sci China Life Sci. 2022 Nov;65(11):2301-2315.

  5. Yingying Zhang, Chenrui An, Yanhong Yu, Jiajing Lin, Long Jin, Chaohui Li, Tao Tan, Yang Yu*, Yong Fan*. Epidermal growth factor induces a trophectoderm lineage transcriptome resembling that of human embryos during reconstruction of blastoids from extended pluripotent stem cells. Cell Prolif. 2022 Jul 26;e13317.

  6. Puyao Zhang, Sengren Xue, Rongrong Guo, Jian Liu, Bing Bai, Dexuan Li, Ahjol Hyraht, Nianqin Sun, Honglian Shao, Yong Fan, Weizhi Ji, Shihua Yang*, Yang Yu*, Tao Tan*. Mapping developmental paths of monkey primordial germ-like cells differentiation from pluripotent stem cells by single cell ribonucleic acid sequencing analysis. Biol Reprod. 2022 Jul 25;107(1):237-249.

  7. Fen-Ting Liu, Shuo Yang, Zi Yang, Ping Zhou, Tianliu Peng, Jingwen Yin, Zhenhong Ye, Hongying Shan, Yang Yu*, Rong Li*. An Altered Microbiota in the Lower and Upper Female Reproductive Tract of Women with Recurrent Spontaneous Abortion. Microbiol Spectr. 2022 Jun 29;10(3):e0046222.

  8. Zheying Min#, Ke Zhong#, Yuxin Luo, Yong Fan, Yang Yu*. Protein Expression Landscape Defines the Formation Potential of Mouse Blastoids From EPSCs. Front. Cell Dev. Biol., Feb 8;10:840492.

  9. Yuxin Luo, Yang Yu*. Research Advances in Gametogenesis and Embryogenesis Using Pluripotent Stem Cells. Front Cell Dev Biol. 2022 Jan 20;9:801468.

  10. Zunpeng Liu#, Wei Li#, Lingling Geng#, Liang Sun#, Qiaoran Wang#, Yang Yu#, Pengze Yan, Chuqian Liang, Jie Ren, Moshi Song, Qian Zhao, Jinghui Lei, Yusheng Cai, Jiaming Li, Kaowen Yan, Zeming Wu, Qun Chu, Jingyi Li, Si Wang, Chunyi Li, Jing-Dong J Han, Reyna Hernandez-Benitez, Ng Shyh-Chang, Juan Carlos Izpisua Belmonte, Weiqi Zhang*, Jing Qu*, Guang-Hui Liu*. Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor. Cell Discov. 2022 Feb 1;8(1):6.

  11. Yang Yu, Hsun-Ming Chang, John Even Schjenken*. Editorial: Reproduction and the Inflammatory Response. Front Endocrinol (Lausanne). 2022 Jan 31;12:835854.

  12. Yong Fan#*, Zheying Min#, Samhan Alsolami#, Zhenglai Ma, E Zhang, Wei Chen, Ke Zhong, Wendi Pei, Xiangjin Kang, Puyao Zhang, Yongliang Wang, Yingying Zhang, Linfeng Zhan, Haiying Zhu, Chenrui An, Rong Li, Jie Qiao, Tao Tan*, Mo Li*, Yang Yu*. Generation of human blastocyst-like structures from pluripotent stem cells. Cell Discov. 2021 Sep 7;7(1):81. 9

  13. Lin Fu, Yu-Xin Luo, Ying Liu, Hui Liu, Hong-Zhen Li, Yang Yu*. Potential of Mitochondrial Genome Editing for Human Fertility Health. Front Genet. 2021 Jul 20;12:673951.

  14. Wendi Pei, Lin Fu, Shui-Qing Li*, Yang Yu*. Brain transcriptomics of nonhuman primates: A review. Neurosci Lett. 2021 May 14;753:135872.

  15. Hai-Ying Zhu#, Xiang-Jin Kang#, Long Jin, Pu-Yao Zhang, Han Wu, Tao Tan, Yang Yu*, Yong Fan*. Histone demethylase KDM4A overexpression improved the efficiency of corrected human tripronuclear zygote development. Mol Hum Reprod. 2021 Feb 27;27(3):gaab012. 1

  16. Tianjie Li, Changyu Liu, Xiumei Zhen, Yang Yu*, Jie Qiao. Actinomycin D causes oocyte maturation failure by inhibiting chromosome separation and spindle assembly. Biology of Reproduction, 2021 Jan 4;104(1):94-105.

  17. Long Jin#, Hai-Ying Zhu#, Xiang-Jin Kang, Li-Ping Lin, Pu-Yao Zhang, Tao Tan, Yang Yu*, Yong Fan*. Melatonin protects against oxybenzone-induced deterioration of mouse oocytes during maturation. Aging (Albany NY). 2020 Dec 29;13(2):2727-2749. 1

  18. Zheying Min#, Xiaoyu Long#, Hongcui Zhao#, Xiumei Zhen, Rong Li, Mo Li, Yong Fan*, Yang Yu*, Yue Zhao*, Jie Qiao. Protein Lysine Acetylation in Ovarian Granulosa Cells Affects Metabolic Homeostasis and Clinical Presentations of Women With Polycystic Ovary Syndrome. Front Cell Dev Biol. 2020 Sep 11;8:567028. 6

  19. Yong Fan#, Congru Li#, Wendi Pei#, Tao Tan, Rong Li, Jie Qiao, Yang Yu*. Transcriptomic analysis reveals gender differences in gene expression profiling of the hypothalamus of rhesus macaque with aging. Aging (Albany NY). 2020 Sep 27;12(18):18251-18273. 1

  20. Pu-Yao Zhang, Yong Fan, Tao Tan* and Yang Yu*. Generation of Artificial Gamete and Embryo From Stem Cells in Reproductive Medicine. Front Bioeng Biotechnol. 2020 Jul 22;8:781. 4

  21. Wenhao Zhang#, Yaru Tian#, Qian Gao#, Xu Li, Yanni Li, Jinxin Zhang, Chunmeng Yao, Yuna Wang, Haoyu Wang, Yiding Zhao, Qian Zhang, Luyuan Li, Yang Yu*, Yong Fan*, Ling Shuai*. Inhibition of Apoptosis Reduces Diploidization of Haploid Mouse Embryonic Stem Cells during Differentiation. Stem Cell Reports. 2020 Jul 14;15(1):185-197. (Cover story) 7

  22. Wen-Di Pei#, Yan Zhang#, Tai-Lang Yin*, Yang Yu*. Epigenome editing by CRISPR/Cas9 in clinical settings: possibilities and challenges. Briefings in Functional Genomics. Brief Funct Genomics. 2020 May 20;19(3):215-228. (IF = 2.941) 3

  23. Si Wang#, Yuxuan Zheng#, Jingyi Li#, Yang Yu#, Weiqi Zhang#, Moshi Song, Zunpeng Liu, Zheying Min, Huifang Hu, Ying Jing, Xiaojuan He, Liang Sun, Lifang Ma, Concepcion Rodriguez Esteban, Piu Chan, Jie Qiao, Qi Zhou, Juan Carlos Izpisua Belmonte*, Jing Qu*, Fuchou Tang*, Guang-Hui Liu*. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Cell. 2020 Feb 6;180(3):585-600. (IF = 36.216) (Cover story) 123

  24. Pu-Yao Zhang, Yang Yu*. Precise Personalized Medicine in Gynecology Cancer and Infertility. Front Cell Dev Biol. 2020 Jan 17;7:382. (IF = 5.206) 7

  25. Senlin Yin#, Keying Lu#, Tao Tan#, Jie Tang#, Jingkuan Wei, Xu Liu, Xinlei Hu, Haisu Wan, Wei Huang, Yong Fan*, Dan Xie*, Yang Yu*. Transcriptomic and open chromatin atlas of high-resolution anatomical regions in the rhesus macaque brain. Nat Commun. 2020 Jan 24;11(1):474. (IF = 11.878) 11

  26. Si Wang, Zheying Min, Qianzhao Ji, Lingling Geng, Yao Su, Zunpeng Liu, Huifang Hu, Lixia Wang, Weiqi Zhang, Keiichiro Suzuiki, Yu Huang, Puyao Zhang, Tie-Shan Tang, Jing Qu*, Yang Yu*, Guang-Hui Liu*, Jie Qiao*. Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction. Protein Cell. 2020 Jan;11(1):1-22. (IF = 7.575) 23

  27. Ronghui Li#, Cuiqing Zhong#, Yang Yu#, Haisong Liu, Masahiro Sakurai, Leqian Yu, Zheying Min, Lei Shi,Yulei Wei, Yuta Takahashi, Hsin-Kai Liao, Jie Qiao, Hongkui Deng, Estrella Nuñez-Delicado, Concepcion Rodriguez Esteban, Jun Wu*, Juan Carlos Izpisua Belmonte*. Generation of blastocyst-like structures from mouse embryonic and adult cell cultures. Cell. 2019 179(3):687-702. (IF = 36.216) 81

  28. Zheying Min, Yue Zhao, Jing Hang, Yun Ren, Tao Tan*, Yong Fan*, Yang Yu*. Neuroendocrine characteristics of induced pluripotent stem cells from polycystic ovary syndrome women. Protein Cell. 2019 10(7):526-532. (IF = 7.575) 3

  29. Yanni Li, Xiang Jin Kang, Jeremy Kah, Sheng Pang, Boon Seng Soh, Yang Yu*, Yong Fan*. Human germline editing: Insights to future clinical treatment of diseases. Protein Cell. 2019 10(7):470-475. (IF = 7.575) 3

  30. Kai-Lun Hu, Hsun-Ming Chang, Hong-Cui Zhao, Yang Yu*, Rong Li*, Jie Qiao. Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation. Human Reproduction Update. 2019 25(3):326-343. (IF = 12.878) 33

  31. Hongcui Zhao, Tianjie Li, Yue Zhao, Tao Tan, Changyu Liu, Yali Liu, Liang Chang, Ning Huang, Chang Li, Yong Fan*, Yang Yu*, Rong Li*, Jie Qiao. Single-cell transcriptomics of human oocytes: environment-driven metabolic competition and compensatory mechanisms during oocyte maturation. Antioxid Redox Signal. 2019 30(4):542-559. (IF = 5.828) 26

  32. Kai-Lun Hu, Hsun-Ming Chang, Rong Li, Yang Yu*, Jie Qiao. Regulation of LH secretion by RFRP-3 - From the hypothalamus to the pituitary. Front Neuroendocrinol. 2019 52:12-21. (IF = 7.852) 22

  33. Zheying Min, Jiangman Gao, Yang Yu*. The roles of mitochondrial SIRT4 in cellular metabolism. Frontiers in Endocrinology. 2019 9:783. (IF = 3.634) 50

  34. Tao Tan†, Lin Xia†, Kailing Tu†, Jie Tang†, Senlin Yin, Lunzhi Dai, Peng Lei, Biao Dong, Hongbo Hu, Yong Fan, Yang Yu*, Dan Xie*. Improved Macaca fascicularis gene annotation reveals evolution of gene expression profiles in multiple tissues. BMC Genomics. 2018 1;19(1):787 (IF = 3.730) 2

  35. Congru Li, Yong Fan, Guoqiang Li, Xiaocui Xu, Jialei Duan, Rong Li, Xiangjin Kang, Xin Ma, Xuepeng Chen, Yuwen Ke, Jie Yan, Ying Lian, Ping Liu, Yue Zhao, Hongcui Zhao, Yaoyong Chen, Yang Yu*, Jiang Liu* DNA methylation reprogramming of functional elements during mammalian embryonic development. Cell Discov. 2018 7;4:41. (IF = 4.462) 32

  36. Zheying Min, Qian Gao, Xiumei Zhen, Yong Fan, Tao Tan, Rong Li, Yue Zhao*, Yang Yu*. New insights into the genic and metabolic characteristics of induced pluripotent stem cells from polycystic ovary syndrome women. Stem Cell Res Ther. 2018 9;9(1):210. (IF = 4.963) 8

  37. Haisong Wang, Wenhao Zhang, Qian Gao, Xiangrong Cao, Yanni Li, Xu Li. Zheying Min, Yang Yu*, Yuanqiang Guo*, Ling Shuai*. Extractive from Hypericum ascyron L promotes serotonergic neuronal differentiation in vitro. Stem Cell Res. 2018 31:42-50. (IF = 3.902) 9

  38. Yanni Li, Xu Li, Haisong Wang, Qian Gao, Jinxin Zhang, Wenhao Zhang, Zhisong Zhang, Luyuan Li, Yang Yu*, Ling Shuai*. CRISPR/Cas9-edited Pax6-GFP reporter system facilitates the generation of mouse neural progenitor cells during differentiation. J Genet Genomics. 2018 Accepted  (IF = 4.066) 3

  39. Kailun Hu, Hongcui Zhao*, Hsun-Ming Chang, Yang Yu*, Jie Qiao. Kisspeptin/Kisspeptin Receptor System in the Ovary. Frontiers in Endocrinology. 2018 8:365. (IF = 3.675) 73

  40. Yi Yang, Han Wu, Xiangjin Kang, Tianjie Li, Tao Tan, Jiangyun Peng, Quanjun Zhang, Geng An, Yali Liu, Qian Yu, Zhenglai Ma, Ying Lian, Boon Seng Soh, Qingfeng Chen, Ping Liu, Yaoyong Chen, Xiaofang Sun, Rong Li, Xiumei Zhen, Yang Yu*, Xiaoping Li*, and Yong Fan*. Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs. Protein Cell. 2018;9(3):283-297. (IF = 6.228) 68

  41. Guoqiang Li#, Yang Yu#, Yong Fan#, Congru Li#, Xiaocui Xu, Jialei Duan, Rong Li, Xiangjin Kang, Xin Ma, Xuepeng Chen, Yuwen Ke, Jie Yan, Ying Lian, Ping Liu, Yue Zhao, Hongcui Zhao, Yaoyong Chen, Xiaofang Sun, Jianqiao Liu, Jie Qiao*, Jiang Liu*. Genome-wide abnormal DNA methylome of human blastocyst in assisted reproductive technology. J Genet Genomics. 2017;44(10):475-481. (IF = 4.051) 22

  42. Kailun Hu, Yang Yu*. Metabolite availability as a window to view the early embryo microenvironment in vivo. Mol Reprod Dev. 2017 Oct;84(10):1027-1038 (IF = 2.316) Review article 12

  43. Hongcui Zhao, Yue Zhao, Yun Ren, Min Li, Tianjie Li, Rong Li, Yang Yu* and Jie Qiao. Epigenetic Regulation of Adverse Metabolic Phenotype in polycystic ovary syndrome: Impact of Leukocyte Methylation of PPARGC1A Promoter. Fertil Steril. 2017;107(2):467-474. (IF = 4.373) 28

  44. Ning Huang, Yang Yu* and Jie Qiao*. Dual role for the unfolded protein response in the ovary: adaption and apoptosis. Protein Cell. 2017;8(1):14-24. (IF = 5.374) Review article 35

  45. Changyu Liu, Min Li, Tianjie Li, Hongcui Zhao, Jin Huang, Yun Wang, Qian Gao, Yang Yu* and Qinghua Shi*. ECAT1 is essential for human oocyte maturation and pre-implantation development of the resulting embryos. Scientific Reports. 2016;6:38192. (IF = 5.228) 9

  46. Ying Huang, Jiangman Gao, Chunmei Zhang, Hongcui Zhao, Yue Zhao*, Rong Li*, Yang Yu* and Jie Qiao. Assessment of growth and metabolism characteristics in offspring of dehydroepiandrosterone-induced polycystic ovary syndrome adults. Reproduction. 2016, 152(6):705-714. (IF = 3.184) 8

  47. Si-Yu Bao, Tian-Jie Li, Xiao-Yu Long, Jin-Juan Zhang, Hong-Cui Zhao, Yun Ren, Yue Zhao, Rong Li, Tao Tan, Yang Yu* and Jie Qiao*. Chemokine Receptor Type 4 (CXCR4) Regulates Migration and Invasion of Trophectoderm Cell in the Human Blastocyst. Biol Reprod. 2016, 95(1):21. (IF = 3.471) 6

  48. Cheng Chen, Yue Zhao, Yang Yu*, Rong Li*, and Jie Qiao. MiR-125b regulates endometrial receptivity by targeting MMP26 in women undergoing IVF-ET with elevated progesterone on HCG priming day. Scientific Reports. 2016, 6, 25302. (IF = 5.228) 21

  49. Hong-Cui Zhao, Ting Ding, Yun Ren, Tian-Jie Li, Rong Li, Yong Fan, Jie Yan, Yue Zhao, Mo Li, Yang Yu*, and Jie Qiao*. Role of Sirt3 in mitochondrial biogenesis and developmental competence of human in vitro matured oocytes. Hum Reprod. 2016, 31(3): 607-622. (IF = 4.621) 51

  50. Jinjuan Zhang, Tianjie Li, Weizhi Ji, Yang Yu*, and Tao Tan*. Rho GDIalpha Modulates Rabbit Trophoblast Stem Cell Survival and Migration. Biol Reprod. 2015, 93(6): 144. (IF = 3.471) 3

  51. Jiangman Gao, Ying Huang, Min Li, Hongcui Zhao, Yue Zhao, Rong Li, Jie Yan*, Yang Yu*, and Jie Qiao. Effect of local basic fibroblast growth factor and vascular endothelial growth factor on subcutaneously allotransplanted ovarian tissue in ovariectomized mice. PLoS One. 2015, 10(7): e0134035. (IF = 3.057) 29

  52. Hongcui Zhao, Yue Zhao, Tianjie Li, Min Li, Junsheng Li, Rong Li, Ping Liu, Yang Yu* and Jie Qiao*. Metabolism alteration in follicular niche: the nexus between intermediary metabolism, mitochondrial function, and classic polycystic ovary syndrome. Free Radical Biology and Medicine. 2015, 86: 295-307. (IF = 5.784) 54

  53. Yang Yu, Liang Chang, Hongcui Zhao, Rong Li, Yong Fan and Jie Qiao*. Chromosome microduplication in somatic cells decreases the genetic stability of human reprogrammed somatic cells and results in pluripotent stem cells. Scientific Reports. 2015, 5: 10114. (IF = 5.228) 14

  54. Yang Yu, Qian Gao, Hong-cui Zhao, Rong Li, Jiang-man Gao, Ting Ding, Si-yu Bao, Yue Zhao, Xiao-fang Sun, Yong Fan* and Jie Qiao*. Ascorbic acid improves pluripotency of human parthenogenetic embryonic stem cells through modifying imprinted gene expression in the Dlk1-Dio3 region. Stem Cell Research & Therapy 2015, 6:69. (IF = 4.504) 5

  55. Yong Fan, Hong-Cui Zhao, Jianqiao Liu, Tao Tan, Ting Ding, Rong Li, Yue Zhao, Jie Yan, Xiaofang Sun, Yang Yu* and Jie Qiao*. Aberrant expression of maternal Plk1 and Dctn3 results in the developmental failure of human in-vivo- and invitro-matured oocytes. Scientific Reports. 2015, 5: 8192. (IF = 5.228) 9

  56. WenYin He, XiangJin Kang, HongZi Du, Bing Song, ZhenYu Lu, Yuling Huang, Ding Wang, Xiaofang Sun, Yang Yu* and Yong Fan*. Defining differentially methylated regions specific for the acquisition of pluripotency and maintenance in human pluripotent stem cells via microarray. Plos one 2014, 9(9): e108350. (IF = 3.234) 14

  57. Min Li., Hong-Cui Zhao., Rong Li*, Yang Yu* and Jie Qiao. Chromosomal aberrations in in-vitro matured oocytes influence implantation and ongoing pregnancy rates in a mouse model undergoing intracytoplasmic sperm injection. Plos One 2014, 9(7): e103347. (Corresponding author) (IF = 3.234) 12

  58. Yong Fan, Rong Li, Jin Huang, Hongcui Zhao, Ting Ding, Xiaofang Sun, Yang Yu*, Jie Qiao*. Improved Efficiency of Microsurgical Enucleated Tripronuclear Zygotes Development and Embryonic Stem Cell Derivation by Supplementing Epidermal Growth Factor, Brain-Derived Neurotrophic Factor, and Insulin-Like Growth Factor-1. Stem Cells Dev. 2014; 23(6): 563-575. (IF = 3.727) 7

  59. Yang Yu, Yue Zhao, Rong Li, Li Li, Hongcui Zhao, Min Li, Jiahao Sha, Qi Zhou, and Jie Qiao*. Assessment of the Risk of Blastomere Biopsy during Preimplantation Genetic Diagnosis in a Mouse Model: Reducing Female Ovary Function with an Increase in Age by Proteomics Method. J Proteome Res. 2013; 12(12):5475-5486. (IF = 5.001) 13

  60. Hong-Cui Zhao, Yue Zhao, Min Li, Jie Yan, Li Li, Rong Li, Ping Liu, Yang Yu*, and Jie Qiao*. Aberrant epigenetic modification in murine brain tissues of offspring from preimplantation genetic diagnosis blastomere biopsies. Biol Reprod. 2013; 89(5):117. (Corresponding author) (IF = 3.451) 34

  61. Yang Yu, Jie Yan, Qiu-Fang Zhang, Li-Ying Yan, Min Li, Qi Zhou and Jie Qiao. Successful reprogramming of differentiated cells by somatic cell nuclear transfer, using in vitro-matured oocytes with a modified activation method. J Tissue Eng Regen Med. 2013; 7: 855-863. (IF = 4.428) 5

  62. Jiang-Man Gao, Jie Yan, Rong Li, Min Li, Li-Ying Yan, Tian-RenWang, Hong-Cui Zhao, Yue Zhao, Yang Yu* and Jie Qiao*. Improvement in the quality of heterotopic allotransplanted mouse ovarian tissues with basic fibroblast growth factor and fibrin hydrogel. Hum Reprod. 2013; 28(10):2784-2793. (IF = 4.585) 49

  63. Min Li, Yue Zhao, Cui H Zhao, Jie Yan, Ying L Yan, Rong Li, Ping Liu, Huai-Liang Feng, Yang Yu*, Jie Qiao*. High FSH decreases the developmental potential of mouse oocytes and resulting fertilized embryos, but does not influence offspring physiology and behaviour in vitro or in vivo. Hum Reprod. 2013; 28(5):1309-1323. (IF = 4.585) 17

  64. Yong Fan, Rong Li, Jin Huang, Yang Yu* and Jie Qiao*. Diploid, but not haploid, human embryonic stem cells can be derived from microsurgically repaired tripronuclear human zygotes. Cell Cycle. 2013; 12(2):302-11. (IF = 5.006) 10

  65. Yang Yu, Jie Yan, Min Li, Liying Yan, Yue Zhao, Ying Lian, Rong Li, Ping Liu and Jie Qiao. Effects of combined epidermal growth factor, brain-derived neurotrophic factor and insulin-like growth factor-1 on human oocyte maturation and early fertilized and cloned embryo development. Hum. Reprod. 2012; 27 (7): 2146-2159. (IF = 4.670) 70

  66. Min Li#, Yang Yu#, Jie Yan, Li-Ying Yan, Yue Zhao, Rong Li, Ping Liu, Aaron J. Hsueh, and Jie Qiao. The Role of Cilostazol, a Phosphodiesterase 3 Inhibitor, on Oocyte Maturation and Subsequent Pregnancy in Mice. PLoS One. 2012; 7(1): e30649. (IF = 3.730) 21

  67. Jie Yan#, Yu Yang#, Yan Liying, Liu Zichuan, Liu Ping, Feng Huailiang, Zhou Qi, Qiao Jie. In vitro maturation of cumulus–partially enclosed immature human oocytes by priming with gonadotropin. Fertil Steril. 2011; 96(3):629-634. (IF = 3.775) 17

  68. Yang Yu, Jie Yan, Zi C. Liu, Li Y. Yan, Min Li, Qi Zhou, Jie Qiao. Optimal timing of oocyte maturation and its relationship with the spindle assembly and developmental competence of in vitro matured human oocytes. Fertil Steril. 2011 Jul;96(1):73-78 (IF = 3.775) 24

  69. Yang Yu, Chun Zhao, Zhuo Lv, Wen Chen, Man Tong, Xuejiang Guo, Liu Wang, Jiayin Liu, Zuomin Zhou, Hui Zhu, Qi Zhou, Jiahao Sha. Microinjection Manipulation Resulted in the Increased Apoptosis of Spermatocytes in Testes from Intracytoplasmic Sperm Injection (ICSI) Derived Mice. PLoS One. 2011; 6(7): e22172. (IF = 4.092) 23

  70. Yuyu Niu#, Yang Yu#, Agnieszka Bernat#, Shihua Yang, Xiechao He, Xiangyu Guo, Dongliang Chen, Yongchang Chen, Shaohui Ji, Wei Si, Yongqin Lv, Tao Tan, Qiang Wei, Hong Wang, Lei Shi, Jean Guan, Xuemei Zhu, Marielle Afanassieff, Pierre Savatier, Kang Zhang, Qi Zhou, Weizhi Ji. Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector. Proc Natl Acad Sci U S A. 2010; 107(41): 17663-17667. (IF = 9.771) 91

  71. Zhengyu Lu#, Wanwan Zhu#, Yang Yu#, Dan Jin, Yunqian Guan, Ruqiang Yao, Yu Alex Zhang, Yunshan Zhang, Qi Zhou. Derivation and long-term culture of human parthenogenetic embryonic stem cells using human foreskin feeders. J Assist Reprod Genet. 2010; 27(6): 285-291. (IF = 1.253) 33

  72. Yang Yu, Jindao Wu, Yong Fan, Zhuo Lv, Xuejiang Guo, Chun Zhao, Rong Zhou, Zhuo Zhang, Fuqiang Wang, Min Xiao, Ling Chen, Hui Zhu, Wen Chen, Min Lin, Jiayin Liu, Zuomin Zhou, Liu Wang, Ran Huo, Qi Zhou, Jiahao Sha. Evaluation of blastomere biopsy using mouse model indicates the potential high-risk of neurodegenerative disorders in the offspring. Molecular & Cellular Proteomics 2009; 8 (7): 1490-1500. (Cover Story) (IF = 8.791) 67

  73. Yang Yu, Qingyun Mai, Xinjie Chen, Liu Wang, Ling Gao, Canquan Zhou, Qi Zhou. Assessment of the developmental competence of human somatic cell nuclear transfer embryos by oocyte morphology classification. Human reproduction 2009; 24 (3): 649-657. (IF = 3.859) 36

  74. Yuyu Niu#, Shihua Yang#, Yang Yu#, Chenhui Ding, Jifeng Yang, Shufen Wang, Shaohui Ji, Xiechao He, Yunhua Xie, Xianghui Tang, Qi Zhou, Weizhi Ji. Impairments in Embryonic Genome Activation in Rhesus Monkey Somatic Cell Nuclear Transfer Embryos. Cloning and Stem Cells 2008; 10 (1): 25-35. (IF = 2.622) 10

  75. Qingyun Mai#, Yang Yu#, Tao Li, Liu Wang, Mei-jue Chen, Shu-zhen Huang, Canquan Zhou, Qi Zhou. Derivation of Human Embryonic Stem Cell Lines from Parthenogenetic Blastocysts. Cell Research 2007; 17:1008-1019. (IF = 4.217) 223

  76. Yang Yu, Chenhui Ding, Eryao Wang, Xinjie Chen, Xuemei Li, Chunli Zhao, Yong Fan, Liu Wang, Nathalie Beaujean, Qi Zhou, Alice Jouneau1m, Weizhi Ji. Piezo-assisted Nuclear Transfer Affects Cloning Efficiency and May Cause Apoptosis. Reproduction 2007; 133: 947-954. (IF = 2.962) 65

社会职务

  • 2022年– 今,Frontiers in Cell and Developmental Biology,副主编

  • 2021年– 今,中国老年学和老年医学学会抗衰老分会,委员

  • 2020年– 今,中华医学会疼痛学分会基础学组,成员

  • 2018年– 今,世界氧化还原生物学协会(SfRBM),特邀会员

  • 2018年– 今,美国生殖生物学学会(SSR),会员

  • 2017年,亚太生殖医学协会第三届高级培训班特邀授课专家

  • 2017年,北京市委组织部青海对口支援专家组成员

  • 2016年 – 今,国家卫健委 “西部孕前优生重点实验室”,客座研究员

  • 2016年– 今,世界华人生物学家协会,终身会员

  • 2016年– 今,国际干细胞研究学会(ISSCR),会员

  • 2016年– 今,美国生殖医学会(ASRM),会员

  • 2016年– 今,国家自然科学基金评审专家

  • 2014年– 今,PLoS ONE杂志,学术编辑

论文审稿

  • Protein Cell、Cell Discov、Hum Reprod、Biol Reprod等国际杂志同行评议专家

  • 国内核心期刊《天津医药》《现代妇产科进展》《中国组织工程研究》等杂志特约审稿人

  • 受邀美国25th/26th/27th/28th/29th Annual Meeting of the Society for Redox Biology and Medicine摘要评审专家/travel awards评审专家

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