工作经历

1994年毕业于山东医科大学，同年获医学学士学位 2002年北京大学博士毕业，同年获医学博士学位

科研工作

先后在国家自然科学基金、国家863课题、国家重点研发计划课题、教育部新世纪优秀人才支持计划的大力支持下，探索骨质疏松、骨折愈合及骨骼退行性病变的临床和基础研究。

1. 科技部重点研发计划，老年常见临床问题防控技术有效集成及综合示范研究

2. 国家自然科学基金，局部施用辛伐他汀抗生物膜及内植物感染的作用及其机制

3. 国家自然科学基金，3D打印多孔钛合金填充辛伐他汀温敏性水凝胶在脊柱融合中的研究

4. 科技部863计划，具有骨诱导作用的可注射载他汀智能体系研发

5. 教育部新世纪优秀人才，骨质疏松和成骨重建应用基础及机制

6. 国家自然科学基金，雌激素受体的表达在辛伐他汀刺激成骨机制中的作用

国家自然科学基金，局部植入辛伐他汀动员自体干细胞归巢在骨缺损修复中的作用

学术兼职

中华医学会骨质疏松与骨矿盐疾病分会委员

北京医学会骨质疏松与骨矿盐疾病分会副主任委员

中国老年医学会骨与关节分会骨质疏松学术工作委员会副主任委员

中国老年医学会医学装备与适老辅具分会副会长

中国老年学和老年医学学会老年骨科分会基础学组组长

《中华医学科研管理杂志》编委

《中华骨质疏松和骨矿盐疾病杂志》编委

获奖情况

全国创新争先奖牌2020年度（4/15）

北京大学优秀教授2015年度

北京大学医学部SCI论文引用奖2012年度

《中华骨科杂志》论坛优秀论文三等奖 2011年

全国卫生系统“创先争优”先进个人2011年

教育部新世纪优秀人才2010年

北京大学医学部优秀青年学者北京大学医学部2009年

国际骨质疏松大会优秀论文三等奖IOC 2007年

北京大学优秀博士论文二等奖北京大学2004年

中华医学会骨科分会第六届全国优秀论文二等奖中华医学会骨科分会2003年

论文

主要论文（近10年来，通讯作者或共同通讯作者）

1. Dang L, Zhu J,Song C*. The effect of topical administration of simvastatin on entochondrostosis and intramembranous ossification: An animal experiment.J Orthop Transl. 2021; 28: 1–9.

2. Zhu J, Zhang C, Jia J, Wang H, Leng H, Xu Y, Wu C, Zhang Q,Song C*. Osteogenic effects in a rat osteoporosis model and femur defect model by simvastatin microcrystals.Ann Ny Acad Sci. 2021; 1487: 31–42.

3. Zhang C,Song C*. Combination Therapy of PTH and Antiresorptive Drugs on Osteoporosis: A Review of Treatment Alternatives.Front Pharmacol. 2021; 11: 607017.

4. Yuan W, Hai B, Ren X, Zhu J, Zhang C, Guan Z, Jia J, Wang H, Cao B,Song C*. Single-dose local intraosseous injection of simvastatin suppresses breast cancer with tumor vascular normalization.Transl Oncol. 2020; 13: 100867.

5. Liu C, Zhu J, Hai B, Zhang W, Wang H, Leng H, Xu Y,Song C*. Single Intraosseous Injection of Simvastatin Promotes Endothelial Progenitor Cell Mobilization, Neovascularization, and Wound Healing in Diabetic Rats.Plast Reconstr Surg. 2020; 145: 433–443.

6. Zhu J, Liu C, Jia J, Zhang C, Yuan W, Leng H, Xu Y,Song C*. Short‐term caloric restriction induced bone loss in both axial and appendicular bones by increasing adiponectin.Ann Ny Acad Sci. 2020; 1474: 47–60.

7. Yuan W,Song C*. The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways.Biochem Res Int. 2020; 2020: 1–10.

8. Zhang C, Zhu J, Jia J, Guan Z, Sun T, Zhang W, Yuan W, Wang H, Leng H,Song C*. Once‐weekly parathyroid hormone combined with ongoing long‐term alendronate treatment promotes osteoporotic fracture healing in ovariectomized rats.J Orthop Res. 2020; 10.1002/jor.24953

9. Zhang C, Feng J, Wang S, Gao P, Xu L, Zhu J, Jia J, Liu L, Liu G, Wang J,Zhan S*, Song C*. Incidence of and trends in hip fracture among adults in urban China: A nationwide retrospective cohort study.Plos Med.2020; 17: e1003180.

10. Guan Z, Jia J, Zhang C, Sun T, Zhang W, Yuan W, Leng H,Song C*. Gut microbiome dysbiosis alleviates the progression of osteoarthritis in mice.Clinical Science. 2020;134:3159–3174.（封面文章）

11. Guan X, Guan Z,Song C*. Expression profile analysis identifies key genes as prognostic markers for metastasis of osteosarcoma.Cancer Cell Int. 2020; 20: 104.

12. Zhang C, Zhu J, Jia J, Guan Z, Sun T, Zhang W, Yuan W, Wang H, Leng H,Song C*Effect of Single Versus Multiple Fractures on Systemic Bone Loss in Mice.J Bone Miner Res. 2020; 10.1002/jbmr.4211

13. Dang L, Zhu J, Liu Z, Liu X, Jiang L, Wei F,Song C*. A new approach to the treatment of spinal instability: Fusion or structural reinforcement without surgery?Med Hypotheses. 2020; 144: 109900.

14. Zhang W, Sun C, Zhu J, Zhang W, Leng H,Song C*. 3D printed porous titanium cages filled with simvastatin hydrogel promotes bone ingrowth and spinal fusion in rhesus macaques.Biomaterials Science. 2020;8:4147–56.（封面文章）

15. Zhang W, Zhu J, Ma T, Liu C, Hai B, Du G, Wang H, Li N, Leng H, Xu Y,Song C*. Comparison of the effects of once-weekly and once-daily rhPTH (1-34) injections on promoting fracture healing in rodents.J Orthop Res. 2018; 36: 1145–1152.

16. Guo Q, Liu C, Hai B, Ma T, Zhang W, Tan J, Fu X, Wang H, Xu Y*,Song C*. Chitosan conduits filled with simvastatin/Pluronic F-127 hydrogel promote peripheral nerve regeneration in rats.J Biomed Mater Res B Appl Biomater. 2018; 106: 787–799.

17. Fu X, Tan J, Sun CG, Leng HJ, Xu YS,Song CL*. Intraosseous Injection of Simvastatin in Poloxamer 407 Hydrogel Improves Pedicle-Screw Fixation in Ovariectomized Minipigs.J Bone Joint Surg Am. 2016; 98: 1924–1932.

18. Liu H, Li W, Liu C, Tan J, Wang H, Hai B, Cai H, Leng H, Liu Z-J,Song C-L*. Incorporating simvastatin/poloxamer 407 hydrogel into 3D-printed porous Ti6Al4V scaffolds for the promotion of angiogenesis, osseointegration and bone ingrowth.Biofabrication. 2016; 8: 045012.

19. Tan J, Fu X, Sun CG, Liu C, Zhang XH, Cui YY, Guo Q, Ma T, Wang H, Du GH, Yin X, Liu ZJ, Leng HJ, Xu YS,Song CL*. A single CT-guided percutaneous intraosseous injection of thermosensitive simvastatin/poloxamer 407 hydrogel enhances vertebral bone formation in ovariectomized minipigs.Osteoporosis Int. 2016; 27: 757–767.

20. Zhang W, Liu C, Hai B, Du G, Wang H, Leng H, Xu Y,Song C*. A Convenient In Vivo Model Using Small Interfering RNA Silencing to Rapidly Assess Skeletal Gene Function.PloS one. 2016;11(11): e0167222-16.

21. Tan J, Yang N, Fu X, Cui Y, Guo Q, Ma T, Yin X, Leng H,Song C*. Single-dose local simvastatin injection improves implant fixation via increased angiogenesis and bone formation in an ovariectomized rat model.Med Sci Monit. 2015; 21: 1428–39.

22. Yang N, Cui Y, Tan J, Fu X, Han X, Leng H,Song C*. Local injection of a single dose of simvastatin augments osteoporotic bone mass in ovariectomized rats.J Bone Miner Metab. 2014; 32: 252–60.

23. Yueyi C, Xiaoguang H, Jingying W, Quansheng S, Jie T, Xin F, Yingsheng X*,Chunli S*. Calvarial defect healing by recruitment of autogenous osteogenic stem cells using locally applied simvastatin.Biomaterials. 2013; 34: 9373–9380.

24. Han X, Yang N, Cui Y, Xu Y, Dang G,Song C*. Simvastatin mobilizes bone marrow stromal cells migrating to injured areas and promotes functional recovery after spinal cord injury in the rat.Neuroscience Lett. 2012; 521: 136–141.

25. Han X, Yang N, Xu Y*, Zhu J, Chen Z, Liu Z, Dang G,Song C*. Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF.Neuroscience Lett. 2011; 487: 255–259.

26. Li X, Song Q-S, Wang J-Y, Leng H, Chen Z-Q, Liu Z-J, Dang G-T,Song C-L*. Simvastatin induces estrogen receptor-alpha expression in bone, restores bone loss, and decreases ERα expression and uterine wet weight in ovariectomized rats.J Bone Miner Metab. 2011; 29: 396–403.

著作与译著

《骨骼研究常用技术》北京大学医学出版社 2019年主译 《现代骨科基础与临床》人民卫生出版社 2006年参编 《骨质疏松椎体压缩性骨折》人民卫生出版社 2007年参译 《创伤骨科学》天津科技翻译出版公司 2007年参译 《衰老相关疾病及综合征》人民卫生出版社 2011年参编