科研工作

除了分子检测工作，本人还参与了多项科研课题的研究，如国家重点研发计划“帕金森病的早期诊断新技术研发”。这其中，本人通过NanoString和数字PCR技术率先在帕金森病患者红细胞中发现一个新的生物标志物，研究成果已投往Science子刊Science Advances，目前处于小修中。

论文

一、期刊论文

1.Xiaodan Liu, Qilong Wang, David Soltys, Min Shi, Tessandra Stewart, Eric Thorland, Eugene M. Cilento, Genliang Liu, Chen Tian, Tao Feng, Jing Zhang. Reduced CHCHD2 mRNA in Erythrocytes: A Robust Marker Reflecting Brain Pathology to Detect Parkinson’s Disease. Science Advances. 2020 Minor revision

2.Liang-Yi Zhu, Xiao-Yu Wu, Xiao-Dan Liu, Dan-Feng Zheng, Hai-Shuang Li, MS, Bao Yang, Jing Zhang, and Qing Chang. Aggressive Medulloblastoma-Derived Exosomal miRNAs Promote In Vitro Invasion and Migration of Tumor Cells Via Ras/MAPK Pathway.J NEN. 2020 Accepted

3.Liu X, Liu X, Wang X, Wu R, Zhang K, Liu B, Liu Q, Shao Y, Tang R, You J, Pei F.A novel case of endometrial dedifferentiated adenocarcinoma associated with MLH1 promotor hypermethylation and microsatellite instability.

Pathol Res Pract. 2018 Nov;214(11):1904-1908.

4.Liu, Xiao-Dan，Yang, Jing-Jing，Fang, Dong，Cai, Jie，Wan You，Xing, Guo-Gang，Functional upregulation of nav1.8 sodium channels on the membrane of dorsal root Ganglia neurons contributes to the development of cancer-induced bone pain.，PLoS One，2014.01.01，9（12）：e114623~e114623

5. 刘小旦，曲春燕，常染色体显性致聋基因KCNQ4的研究进展，中国听力语言康复科学杂志，2016.01.01，14（4）

6.Fang, Dong，Kong, Ling-Yu，Cai, Jie，Li, Song，Liu, Xiao-Dan，Han, Ji-Sheng，Xing, Guo-Gang ，Interleukin-6-mediated functional upregulation of TRPV1 receptors in dorsal root ganglion neurons through the activation of JAK/PI3K signaling pathway: roles in the development of bone cancer pain in a rat model，Pain，2015.6.01，156（6）：1124~1144

7.Ding, Xu，Cai, Jie，Li, Song，Liu, Xiao-Dan，Wan, You，Xing, Guo-Gang BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation，Neurobiology of Disease，2015.1.01，73：428~451

8.Cai, Jie ，Fang, Dong，Li, Song，Ren, Juan，Liu, Xiao-Dan， Xing,Guo-Gang，Suppression of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to the sensitization of dorsal horn WDR neurons and pain hypersensitivity in a rat model of bone cancer pain.，Oncol Rep，2015.3.01，33（3）：1540~1550

9.Geng, Shan-Jing，Liao, Fei-Fei，Dang, Wen-Hao，Ding, Xu，Liu, Xiao-Dan ，Cai, Jie，Han, Ji-Sheng，Wan, You，Xing, Guo-Gang，Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation，Experimental Neurology，2010.4.4，222（2）：256~266